The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ.

Autor: Tikhomirova LN; Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Medvedeva YS; Department of Physico-Chemical and Environmental Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Lebedeva MA; Department of Physico-Chemical and Environmental Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Gavrilov IY; Department of Bioengineer Technologies and Scientific Research Support, V. N. Smirnov Research Institute of Experimental Cardiology, National Medical Research Centre of Cardiology named after academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia., Revenko SV; Department of Heart Electrophysiology, V. N. Smirnov Research Institute of Experimental Cardiology, National Medical Research Centre of Cardiology named after academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia. s_revenko@mail.ru., Karganov MY; Department of Physico-Chemical and Environmental Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Popov EG; Department of Bioengineer Technologies and Scientific Research Support, V. N. Smirnov Research Institute of Experimental Cardiology, National Medical Research Centre of Cardiology named after academician E. I. Chazov, Ministry of Health of the Russian Federation, Moscow, Russia., Tarakanov IA; Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Nov; Vol. 178 (1), pp. 24-29. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1007/s10517-024-06276-9
Abstrakt: The rheographic parameters of the segments of brachial and femoral arteries were measured in situ after a 14-day-long hindlimb unloading (HU) of rats. HU significantly increased electrical impedance Z of a segment of femoral artery indicating its constriction; in parallel, HU resulted in a decreasing trend of Z of a segment of brachial artery attesting to its dilation. In both arteries, HU significantly or as a trend decreased the swing ranges of active and passive pulsations, respectively. BP reduction during bloodletting induced transition from passive to active pulsatile mode in the femoral artery only in 33% experimental rats in contrast to 87% control ones. We suppose that degradation of active pulsatile mode is responsible for the negative influences of microgravity and weightlessness on blood circulation. The study determined the rheographic parameters that reliably reflect changes in the functional activity of arteries after chronic redistribution of hydrostatic load.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: