Obstructive sleep apnea in 12 to 24 months old toddlers referred for sleep study in a tertiary care center.
| Autor: | Senthilvel E; Department of Pediatrics, University of Louisville and Norton Children Medical Group, 9880 Angies Way Suite 300, Louisville, Kentucky, KY 40241, USA. Egambaram.senthilvel@louisville.edu., Kluthe T; Department of Pediatrics, University of Louisville and Norton Children Medical Group, 9880 Angies Way Suite 300, Louisville, Kentucky, KY 40241, USA., Nguyen QL; Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Louisville School Medicine, Louisville, Kentucky, USA., Shah C; Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, USA., Kinney M; Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, USA., Feller C; Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, USA., Betz K; Department of Pediatrics, Norton Children Medical Group, Louisville, Kentucky, USA., Sivaram G; Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Louisville School Medicine, Louisville, Kentucky, USA., Jawad K; Department of Pediatrics, University of Louisville and Norton Children Medical Group, 9880 Angies Way Suite 300, Louisville, Kentucky, KY 40241, USA., El-Kersh K; Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Arizona College of Medicine, Phoenix, Arizona, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Sleep & breathing = Schlaf & Atmung [Sleep Breath] 2024 Nov 22; Vol. 29 (1), pp. 1. Date of Electronic Publication: 2024 Nov 22. |
| DOI: | 10.1007/s11325-024-03179-x |
| Abstrakt: | Purpose: To assess OSA prevalence, comorbidities, and the influence of sleep stages and body positions on respiratory events distribution in toddlers aged 12-24 months. Methods: A single center retrospective study that included toddlers aged 12-24 months old who underwent overnight PSG. OSA severity was categorized by obstructive apnea-hypopnea index (OAHI) as mild (1-4.9 events/h), moderate (5-9.9 events/h), and severe (≥ 10 events/h). Results: 283 PSG data were included with a median age of 18 months (IQR 16-20.25) for the OSA group (168/283) and 19 months (IQR 16-22) for the non-OSA group (115/283) (p = 0.047). OSA prevalence was 68.5% (42.3% mild, 18.5% moderate, and 39% severe). 38.1% of children had no comorbidities, 24.4% had a history of prematurity and 11.3% had Down syndrome. Multivariate binominal regression analysis showed that children with history of prematurity (p = 0.017) and Down syndrome (p = 0.043) had higher odds of having OSA. The mean SaO Conclusion: In toddlers aged 12-24 months, history of prematurity and Down syndrome were significantly associated with OSA. Obstructive respiratory events occurred predominantly in REM sleep, and no significant positional relations were noted. Competing Interests: Declarations. Ethical approval: This retrospective chart review study involving human participant were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The Human Investigation Committee (IRB) of the University of Louisville and Norton Healthcare approved this study. Informed consent: For this type of study formal consent is not required. Conflict of interest: Dr. El-Kersh is a consultant for United Therapeutics, J&J, and Merck. The other authors do not have any financial or non-financial conflict of interest disclosure. (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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