Omphalocele prevalence and co-occurring malformations: a nationwide register-based study of Danish live births in 1997-2021.

Autor: Lausten-Thomsen U; Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. ulrik.lausten-thomsen@regionh.dk.; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark. ulrik.lausten-thomsen@regionh.dk., Hedley PL; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA., Conway KM; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA., Løfberg KM; Department of Pediatric Surgery, University Hospital Rigshospitalet, Copenhagen, Denmark., Johansen LS; Department of Pediatric Surgery, University Hospital Rigshospitalet, Copenhagen, Denmark., Romitti PA; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA., Christiansen M; Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USA.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Pediatric surgery international [Pediatr Surg Int] 2024 Nov 22; Vol. 41 (1), pp. 1. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1007/s00383-024-05897-5
Abstrakt: Purpose: Omphalocele is a congenital abdominal wall defect associated with a high risk of morbidity and mortality, with co-occurring congenital malformations often being the most important prognostic factor. High rates of spontaneous and medical terminations have been reported among pregnancies with omphalocele and co-occurring malformations. Few studies have focused on co-occurring malformations, particularly non-gastrointestinal malformations among live births. This study examined birth prevalence of omphalocele and co-occurring major malformations among a 25-year Danish liveborn cohort.
Methods: This nationwide retrospective prevalence study used data from the Danish National Patient Register and Danish Civil Registration System for infants who were delivered in Denmark during 1997-2021 and included in the Danish neonatal screening biobank. Diagnoses of omphalocele and co-occurring malformations were ascertained and prevalence estimated using Poisson regression.
Results: Among 1,498,685 live births, 147 infants with omphalocele were identified, yielding a combined and stable prevalence (per 10,000 infants) of 0.98 (95% CI 0.83-1.15). Over one-half (53.7%) presented with one or more major malformations, and an additional 17.0% were diagnosed with a syndrome.
Conclusions: Omphalocele birth prevalence in Denmark was stable over a recent 25-year period. The proportion of infants with co-occurring major malformations or diagnosed syndrome has important implications for long-term healthcare demands.
Competing Interests: Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Previous communication: This is the first submission of the manuscript to the journal. This manuscript or parts of it is not being considered for publication by another journal, nor has it been published or posted elsewhere. Ethical considerations: All data were from publicly available sources; thus, approvals from neither scientific ethics committees nor data authorities were required as per Danish law and regulations. Declaration of generative AI in scientific writing: AI and/or AI-assisted technologies were not used in the writing of this manuscript.
(© 2024. The Author(s).)
Databáze: MEDLINE
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