Lung function outcomes in adults born extremely preterm across three decades of advancing perinatal medicine.

Autor: Bårdsen T; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Satrell E; Department of Paediatric and Adolescent medicine, Oslo University Hospital, Oslo, Norway., Drange Røksund O; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.; Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway., Røineland Benestad M; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.; Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway., Hufthammer KO; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.; Centre for Care Research West, Western Norway University of Applied Sciences, Bergen, Norway., Clemm H; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.; Institute of Sports Medicine, Norwegian School of Sports Science, Oslo, Norway., Bruun Mikalsen I; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Paediatric and Adolescent Medicine, Stavanger University Hospital, Stavanger, Norway., Øymar K; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Paediatric and Adolescent Medicine, Stavanger University Hospital, Stavanger, Norway., Halvorsen T; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Vollsæter M; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1111/apa.17498
Abstrakt: Aim: Advances in perinatal medicine from 1980 to 2000 improved survival in extremely preterm (EP) neonates. Long-term effects of these developments remain unclear, and we aimed to investigate potential cohort effects on adult lung function.
Methods: Three 18-year-old population-based cohorts born at ≤28 weeks gestation or with birthweight ≤1000 g during 1982-85, 1991-92 and 1999-2000 and term-controls underwent spirometry, body plethysmography, and tests of lung diffusing capacity, bronchodilator reversibility, and airway hyperresponsiveness. We used Welch's t-tests to compare term- with EP-born as a group and split by bronchopulmonary dysplasia (BPD), and regression models to test group/cohort interactions.
Results: In all EP-born cohorts, z-scores for FEV 1 , FEV 1 /FVC, FEF 25%-75% , DLCO and KCO were reduced compared with term-born. For the 82-85, 91-92 and 99-00 cohorts, deficits for z-FEV 1 and z-DLCO were 1.23 and 0.53; 0.68 and 0.92; and 0.51 and 0.57, respectively (p ≤0.01 for all). Cohort analyses showed stable lung function across the three cohorts overall, but improvements across cohorts for the BPD subgroups in z-FEV 1 , z-FEV 1 /FVC, and z-FEF 25%-75% .
Conclusion: Adults born EP across three formative decades of neonatal care had stable lung function overall, with notable improvements in BPD subgroups across cohorts.
(© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
Externí odkaz: