Synthetic Biomolecular Condensates: Phase-Separation Control, Cytomimetic Modelling and Emerging Biomedical Potential.

Autor: Cao S; Max-Planck-Institut fur Polymerforschung, Department of physical chemistry, Ackermannweg 10, 55128, Mainz, GERMANY., Song S; Mainz University: Johannes Gutenberg Universitat Mainz, Department of Chemistry, GERMANY., Ivanov T; MPIP: Max-Planck-Institut fur Polymerforschung, Department of physical chemistry, GERMANY., Doan-Nguyen TP; MPIP: Max-Planck-Institut fur Polymerforschung, Department of physical chemistry, GERMANY., Caire da Silva L; McGill University, Department of Chemistry, CANADA., Xie J; Sichuan University West China School of Basic Medical Sciences and Forensic Medicine, Insitute of Biomedical Engineering, CHINA., Landfester K; MPIP: Max-Planck-Institut fur Polymerforschung, Department of physical chemistry, GERMANY.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 22, pp. e202418431. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1002/anie.202418431
Abstrakt: Liquid-liquid phase separation towards the formation of synthetic coacervate droplets represents a rapidly advancing frontier in the fields of synthetic biology, material science, and biomedicine. These artificial constructures mimic the biophysical principles and dynamic features of natural biomolecular condensates that are pivotal for cellular regulation and organization. Via adapting biological concepts, synthetic condensates with dynamic phase-separation control provide crucial insights into the fundamental cell processes and regulation of complex biological pathways. They are increasingly designed with the ability to display more complex and ambitious cell-like features and behaviors, which offer innovative solutions for cytomimetic modeling and engineering active materials with sophisticated functions. In this minireview, we highlight recent advancements in the design and construction of synthetic coacervate droplets; including their biomimicry structure and organization to replicate life-like properties and behaviors, and the dynamic control towards engineering active coacervates. Moreover, we highlight the unique applications of synthetic coacervates as catalytic centers and promising delivery vehicles, so that these biomimicry assemblies can be translated into practical applications.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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