Implications of the microbiome after pancreatic cancer resection with regard to morbidity and mortality.

Autor: Merali N; Section of Oncology, Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.; Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK.; Hepato-Pancreato-Biliary (HPB) Surgical Unit, Royal Surrey NHS Foundation Trust, Guildford, UK., Chouari T; Section of Oncology, Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.; Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK.; Hepato-Pancreato-Biliary (HPB) Surgical Unit, Royal Surrey NHS Foundation Trust, Guildford, UK., Junjun S; Department of Gastrointestinal and pancreatic surgery, Shanxi Provincial People's Hospital, Taiyuan, China., Rockall TA; Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK., Giovannetti E; Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.; Cancer Pharmacology Lab, Fondazione Pisana per la Scienza, San Giuliano, Pisa, Italy., Annels N; Section of Oncology, Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK., Frampton AE; Section of Oncology, Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.; Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK.; Hepato-Pancreato-Biliary (HPB) Surgical Unit, Royal Surrey NHS Foundation Trust, Guildford, UK.
Jazyk: angličtina
Zdroj: Expert review of gastroenterology & hepatology [Expert Rev Gastroenterol Hepatol] 2024 Nov; Vol. 18 (11), pp. 689-692. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1080/17474124.2024.2427648
Abstrakt: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with an extremely poor prognosis. The most common complications after a pancreaticoduodenectomy (PD) include surgical site infection (SSI), postoperative pancreatic fistula (POPF), and delayed gastric emptying (DGE). The potential role and mechanisms of microbial colonization of key surgical sites resulting in perioperative complications after PD remain to be fully elucidated. In this key paper evaluation, the role of different microbiota in perioperative morbidity and mortality following PD are discussed, and key microbial signatures are identified that may shape the future management of post-operative surgical care.
Databáze: MEDLINE