Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases.

Autor: Manou M; Department of Hygiene and Epidemiology, School of Medicine University of Ioannina Greece.; Biomedical Research Foundation of the Academy of Athens Athens Greece., Papagiannopoulos C; Department of Hygiene and Epidemiology, School of Medicine University of Ioannina Greece., Chalitsios CV; Department of Hygiene and Epidemiology, School of Medicine University of Ioannina Greece., Asimakopoulos AG; Department of Hygiene and Epidemiology, School of Medicine University of Ioannina Greece., Markozannes G; Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London United Kingdom., Bulló M; Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology Rovira i Virgili University (URV) Reus Spain.; Institute of Health Pere Virgili (IISPV) Reus Spain.; Center of Environmental, Food and Toxicological Technology - TecnATox Rovira i Virgili University Reus Spain.; CIBER Physiology of Obesity and Nutrition (CIBEROBN) Carlos III Health Institute Madrid Spain., Tsilidis KK; Department of Hygiene and Epidemiology, School of Medicine University of Ioannina Greece.; Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London United Kingdom., Papandreou C; Department of Hygiene and Epidemiology, School of Medicine University of Ioannina Greece.; Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology Rovira i Virgili University (URV) Reus Spain.; Institute of Health Pere Virgili (IISPV) Reus Spain.; Center of Environmental, Food and Toxicological Technology - TecnATox Rovira i Virgili University Reus Spain.; Department of Nutrition and Dietetics Sciences, School of Health Sciences Hellenic Mediterranean University (HMU) Siteia Greece., Tzoulaki I; Biomedical Research Foundation of the Academy of Athens Athens Greece.; Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London United Kingdom.
Jazyk: angličtina
Zdroj: Journal of the American Heart Association [J Am Heart Assoc] 2024 Dec 03; Vol. 13 (23), pp. e036573. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1161/JAHA.124.036573
Abstrakt: Background: The underlying biological mechanisms linking blood pressure (BP) and cardiovascular diseases (CVD) are only partly understood. We aimed to identify metabolic signatures associated with systolic and diastolic BP and investigate their subsequent association with risk of CVD.
Methods and Results: The study included 201 742 UK Biobank participants with measurements on 249 metabolic biomarkers. A multistep adaptive elastic net penalized regression with 10-fold cross-validation was employed to identify metabolic signatures for systolic BP and diastolic BP. External validation was conducted on 848 participants from the EHS (Epirus Health Study). We further assessed the associations between BP metabolic signatures and incident composite CVD (N=6742), myocardial infarction (N=4192), and stroke (N=2757) in the UK Biobank, using multivariable Cox regression models. The metabolic signatures comprised 31 and 25 metabolites, robustly correlated with systolic BP and diastolic BP, respectively, in both the UK Biobank and the EHS. Following adjustments (including BP), the metabolic signature for systolic BP was positively associated with incident myocardial infarction (hazard ratio [HR], 1.11 [95% CI, 1.07-1.15]) and CVD (HR, 1.07 [95% CI, 1.04-1.10]). Similarly, the metabolic signature for diastolic BP was associated with a higher risk of myocardial infarction (HR, 1.16 [95% CI, 1.12-1.20]) and CVD (HR, 1.09 [95% CI, 1.05-1.12]). The associations between the signatures and stroke were not significant. The metabolic signatures partly mediated the total effect of the BP traits on the risk of myocardial infarction and CVD.
Conclusions: Our findings may enhance our understanding of the biological mechanisms through which BP affects CVD.
Databáze: MEDLINE
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