Epidemiology and Antibiotic Resistance Patterns of Klebsiella pneumoniae Infections Among Male Patients in a Long-Term Care Hospital in Riyadh, Saudi Arabia: A Retrospective Study.

Autor:	Alfaifi BA; Infection Control, Long Term Care Hospital, Riyadh, SAU., Alkhaldi SA; Research Center, King Saud Medical City, Riyadh, SAU., Alanazi MD; Internal Medicine, Long Term Care Hospital, Riyadh, SAU., Shuraim WA; Infection Control, Long Term Care Hospital, Riyadh, SAU., Aldossry MA; Infection Control, Long Term Care Hospital, Riyadh, SAU., Alzahrani HS; Infection Control, Long Term Care Hospital, Riyadh, SAU., Alhaitei FA; Infection Control, Long Term Care Hospital, Riyadh, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 22; Vol. 16 (10), pp. e72101. Date of Electronic Publication: 2024 Oct 22 (Print Publication: 2024).
DOI:	10.7759/cureus.72101
Abstrakt:	Background: Klebsiella pneumoniae is an opportunistic pathogen commonly found in the normal flora of the gastrointestinal tract. While it typically remains benign, it can lead to severe healthcare-associated infections, particularly among immunocompromised individuals and those in long-term care settings. This study aimed to investigate the epidemiology and antibiotic resistance patterns of K. pneumoniae infections among male patients in a long-term care hospital. Methods: A retrospective cross-sectional study was conducted, analyzing microbial culture data from 29 male patients admitted to the male ward of a long-term care hospital in Riyadh, Saudi Arabia. The study included patients with confirmed positive cultures for K. pneumoniae . Data were collected regarding demographic information, culture sites, and antibiotic susceptibility test results. Statistical analysis was performed to identify significant associations between patient characteristics and resistance patterns, with a particular focus on the prevalence of carbapenem-resistant Enterobacterales (CRE) and the production of extended-spectrum beta-lactamases (ESBL). Results: Around 51.7% of the K. pneumoniae isolates were found to be resistant to carbapenems, while 24.1% were classified as producers of ESBL. Patients suffering from bedsores had a significantly higher prevalence of CRE infections at 37.9% compared to only 13.8% in patients without bedsores (p=0.034). The analysis also indicated that older patients (aged over 50 years) exhibited a higher prevalence of CRE infections (34.5%) compared to their younger counterparts (17.2%, p=0.069). Notably, resistance levels against antibiotics were high, with 75.9% of isolates resistant to cotrimoxazole, 65.5% to ciprofloxacin, and 62.1% to gentamicin. In contrast, imipenem and meropenem showed relatively higher susceptibility, with each antibiotic having a susceptibility rate of 34.5%. Conclusion: There is a significant prevalence of multidrug-resistant K. pneumoniae infections in long-term care environments, particularly affecting older male patients and those with bedsores. These findings underscore the need for targeted infection control measures and enhanced antibiotic stewardship programs. Future research should include both genders to investigate epidemiological differences and broader resistance trends. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Alfaifi et al.)
Databáze:	MEDLINE
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