Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer.

Autor:	Chang AC; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Balic M; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Bartholow T; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pathology, Pittsburgh PA, USA., Bhargava R; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pathology, Pittsburgh PA, USA., Brown DD; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Institute of Precision Medicine, Pittsburgh PA, USA., Brown L; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Brufsky A; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Cao Y; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Carleton N; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Clark AM; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pathology, Pittsburgh PA, USA., Cody M; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Ding K; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Deible C; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Elangovan A; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Foldi J; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Geisler D; Department of Radiology, UPMC, Pittsburgh PA, USA., Hodgdon C; GRASP, Boston, MA, USA., Howard N; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh PA, USA.; School of Nursing, Pittsburgh PA, USA.; Department of Pathology, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA.; Department of Human Genetics, Pittsburgh PA, USA.; Institute of Precision Medicine, Pittsburgh PA, USA.; Department of Radiology, UPMC, Pittsburgh PA, USA.; School of Bioengineering, Pittsburgh PA, USA.; NSABP, Pittsburgh PA, USA.; bcRAN, Pittsburgh PA, USA.; MBC Alliance, Boston, MA, USA.; LBBC, Boston, MA, USA.; GRASP, Boston, MA, USA.; Moffitt Cancer Center. Boston, MA, USA.; Cincinnati Children's Hospital Medical Center. Boston, MA, USA.; DFCI/Broad Institute of MIT and Harvard. Boston, MA, USA., Li Z; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Liu JB; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Lopez-Nunez O; Department of Pathology, Pittsburgh PA, USA.; Cincinnati Children's Hospital Medical Center. Boston, MA, USA., Mary SJ; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., McGinn O; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Miller L; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA., Mori K; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Pecar G; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Priedigkeit N; DFCI/Broad Institute of MIT and Harvard. Boston, MA, USA., Puhalla S; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA.; NSABP, Pittsburgh PA, USA., Rosenzweig MQ; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; School of Nursing, Pittsburgh PA, USA., Roy P; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; School of Bioengineering, Pittsburgh PA, USA., Savariau L; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Walker S; MBC Alliance, Boston, MA, USA.; LBBC, Boston, MA, USA., Waltermire H; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Wedn AM; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh PA, USA., Wells A; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pathology, Pittsburgh PA, USA., Yates ME; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Xavier J; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Medicine, Pittsburgh PA, USA., Lee AV; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh PA, USA.; Institute of Precision Medicine, Pittsburgh PA, USA., Oesterreich S; Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women Research Institute, Pittsburgh PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh PA, USA.; School of Nursing, Pittsburgh PA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.
DOI:	10.1101/2024.11.06.621982
Abstrakt:	Breast cancer affects 1/8 of women throughout their lifetimes, with 90% of cancer deaths being caused by metastasis. However, metastasis poses unique challenges to research, as complex changes in the microenvironment in different metastatic sites and difficulty obtaining tissue for study hinder the ability to examine in depth the changes that occur during metastasis. Rapid autopsy programs thus fill a unique need in advancing metastasis research. Here, we describe our protocol and processes for establishing and improving the US-based Hope for OTHERS (Our Tissue Helping Enhance Research and Science) program for organ donation in metastatic breast cancer. Our results reveal key logistical and protocol improvements that are uniquely beneficial to certain programs based on identifiable features, such as working closely with patient advocates, methods to rescue RNA quality in cases where tissue quality may degrade due to time delays, as well as guidelines and future expansions of our program with new research and novel research findings in patient outcomes, metastatic phylogeny, living model development and more. Competing Interests: Conflict of Interest Statement The authors have no conflicts of interest related to this work. Author RB is a former consultant for GE Health (now ended), and current Speaker’s Bureau member for AstraZeneca. Author AB is a current consultant for AstraZeneca, Pfizer, Novartis, Lilly, Genentech/Roche, Daiichi Sankyo, Merck, Agendia, Sanofi, Puma, Myriad, Gilead, Bria-Cell, and receives research support from Agendia and AstraZeneca.
Databáze:	MEDLINE
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