| Autor: |
Umemoto K, Tomomatsu K; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. k.tomomatu@gmail.com., Urata M, Okazaki E, Yamazaki K, Yoshikawa T, Okada N, Hattori S, Takeuchi T, Horio Y, Takiguchi H, Niimi K, Hayama N, Ito Y, Imazeki R, Oguma T, Nagata E, Asano K |
| Jazyk: |
angličtina |
| Zdroj: |
The Tokai journal of experimental and clinical medicine [Tokai J Exp Clin Med] 2024 Dec 20; Vol. 49 (4), pp. 144-147. Date of Electronic Publication: 2024 Dec 20. |
| Abstrakt: |
Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic neurological syndrome complication of small cell lung cancer (SCLC). The clinical symptoms of LEMS overlap with those of myasthenia gravis (MG), leading to misdiagnosis. Herein, we report two cases of SCLC with LEMS-like disease that were difficult to distinguish from MG because of atypical electromyographic findings without waxing patterns on high-frequency stimulation. Both patients responded poorly to oral pyridostigmine and intravenous immunoglobulin, and were reported to be positive for the anti-P/Q-type voltage-gated calcium channel antibody characteristic of LEMS. Differentiating between LEMS and MG based on clinical symptoms and EMG findings can be difficult. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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