Annexin levels in GCF determine the imbalance of periodontal inflammatory regulation.

Autor: Yilmaz M; Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.; Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, Kavacık Street Ekinciler Avenue Number 19 Kavacık Intersection, Beykoz / İstanbul, 34810, Turkey., Bal İ; Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.; Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, Kavacık Street Ekinciler Avenue Number 19 Kavacık Intersection, Beykoz / İstanbul, 34810, Turkey., Hanli S; Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.; Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, Kavacık Street Ekinciler Avenue Number 19 Kavacık Intersection, Beykoz / İstanbul, 34810, Turkey., Turkmen E; Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.; Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, Kavacık Street Ekinciler Avenue Number 19 Kavacık Intersection, Beykoz / İstanbul, 34810, Turkey., Balci N; Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey. nbalci@medipol.edu.tr.; Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, Kavacık Street Ekinciler Avenue Number 19 Kavacık Intersection, Beykoz / İstanbul, 34810, Turkey. nbalci@medipol.edu.tr., Toygar HU; Department of Periodontology, Institute of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.; Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University, Kavacık Street Ekinciler Avenue Number 19 Kavacık Intersection, Beykoz / İstanbul, 34810, Turkey.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 21; Vol. 14 (1), pp. 28833. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1038/s41598-024-80418-x
Abstrakt: Objective: Annexin-1 (ANXA1), a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while annexin-2 (ANXA2) is involved in the initiation of the inflammatory responses. The aim of this study was to determine the effects of annexin family (ANXA1 and ANXA2) in periodontal disease.
Methods: Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and the periodontal inflamed surface area (PISA) levels were noted. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the ANXA1, ANXA2 and IL-1β levels.
Results: Salivary and serum concentrations of ANXA1 was significantly lower in the periodontitis group than in the control group (respectively, p = 0.0177 and p = < 0.0001). Periodontitis patients demonstrated higher serum ANXA2 and IL-1β concentrations compared to controls (respectively, p = 0.0002 and p = 0.0017). As an inflammatory index; saliva, serum and GCF ANXA1/ANXA2 ratio were significantly lower in the periodontitis group compared to healthy controls.
Conclusions: The data suggest that periodontitis is associated with a disruption of the balance between pro-inflammatory mechanisms (ANXA2 and IL-1beta) and inflammation resolution (ANXA1), in parallel with PISA levels.
Clinical Trial Registration: ClinicalTrials.gov NCT06554756 (15/08/2024).
Competing Interests: Declarations. Ethics approval and consent to participate: All subjects were signed the informed consent from designed for this study. The present study was approved by the human subject ethics board of Istanbul Medipol University (date: 11.08.2023; Number: 635) for the use and access of human subjects in research and was conducted in accordance with the Helsinki Declaration of 1975, as revised in 2013. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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