OCT analysis and MPOD assessment in patients affected by retinitis pigmentosa.

Autor: Ruggeri ML; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy., Baroni LB; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy., Passamonti M; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy., Quarta A; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy. cnatvr00@gmail.com., Lorenzi C; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy., Formenti F; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy., Giansante R; Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy.; Department of Medical Genetics, 'G. d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy., Porreca A; Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy., Di Nicola M; Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy., Toto L; Ophthalmology Clinic, Department of Medicine and Science of Ageing, 'G. d'Annunzio' University, Chieti-Pescara, 66100, Chieti, Italy., Stuppia L; Center for Advanced Studies and Technology (CAST), 'G. d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy.; Department of Psychological, Health and Territorial Sciences, 'G.d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy., Mastropasqua R; Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University Chieti-Pescara, 66100, Chieti, Italy.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 21; Vol. 14 (1), pp. 28830. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1038/s41598-024-79979-8
Abstrakt: This study aimed to analyze Optical Coherence Tomography (OCT) parameters and Macular Pigment Optical Density (MPOD) changes in patients affected by Retinitis pigmentosa (RP). Eighteen eyes of 18 patients suffering from early-stage RP were enrolled in our observational study. 18 eyes of 18 patients age and gender matched were enrolled as controls. Patients were analyzed at baseline by undergoing complete baseline ophthalmologic examination, Spectral-domain Optical Coherence Tomography (OCT), Electroretinogram (ERG) and Heterochromatic Flicker Photometry (HFP). Main outcome measures were Macular Pigment Optical Density (MPOD), Central macular thickness (CMT), Central Choroidal Thickness (CCT) and Choroidal Vascularity Index (CVI). Lower CCT (p = 0.006), CVI (p < 0.001) and MPOD levels (p = 0.038) were found in affected patients, whereas higher CMT was detected in cases compared to healthy controls. Correlation analysis revealed the presence of a negative correlation between BCVA and Age and CMT and BCVA and a positive correlation between CCT and MPOD and CVI and CCT. Retinal and choroidal variations occur in patients affected by early-stage RP regarding functional and anatomical changes.
Competing Interests: Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University “G. d’Annunzio”of Chieti- Pescara. Informed consent was obtained from all subjects involved in the study. Consent for publication: Consent was obtained from all subjects involved in the study. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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