LATS2 and FAT4 as key candidate genes of hippo pathway associated with the risk and progression of breast cancer: an in-silico approach.

Autor: Sadaf; Department of Biotechnology, Jamia Millia Islamia, New Delhi, India., Zafar M; Department of Family and Community Medicine, College of Medicine, University of Ha'il, Ha'il, 2440, Saudi Arabia., Massey S; Department of Biosciences, Jamia Millia Islamia, New Delhi, India., Aloliqi AA; Department of Basic health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, 51542, Saudi Arabia., Anwar S; Department of Biochemistry, College of Medicine, University of Ha'il, Ha'il, 2440, Saudi Arabia., Ali A; Department of Ophthalmology, College of Medicine, University of Ha'il, Ha'il, 2440, Saudi Arabia., Hussain MA; Department of Pathology, College of Medicine, University of Ha'il, Ha'il, 2440, Saudi Arabia., Bhardwaj T; Department of Biological Sciences, University of Calgary, Calgary, Canada., Dev K; Department of Biotechnology, Jamia Millia Islamia, New Delhi, India. kdev@jmi.ac.in.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 21; Vol. 14 (1), pp. 28857. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1038/s41598-024-79688-2
Abstrakt: Background: The 2020 cancer report states that breast cancer remains a significant cause of death for females, despite the use of various strategies for early detection and treatment. However, there are still gaps in the fight against this disease. Researchers are exploring the hippo pathway, one of eight significant pathways involved in cancer progression, for potential biomarkers to use in personalized therapeutics.
Methods: The current study used bioinformatic tools such as DEGs analysis, Methsurv, Km Plotter to generate data that can predict molecular biomarkers associated with hippo pathway in breast cancer development and treatment. The protein-protein interaction pathway was generated using the STRING database to find associations of hippo pathway genes with other dysregulated genes in breast cancer datasets. A disease enrichment study was also done to explore the potential of the hippo pathway in various aspects.
Results: LATS2 and FAT4 genes of the hippo pathway have shown an interesting association with overall survival, hypermethylation, genetic alterations, and decreased expression levels in the breast cancer cohort. Our findings suggest that both of these genes are associated with breast cancer progression and diagnosis and can be utilized as predictive biomarkers by oncologists for personalized therapy in patients.
Competing Interests: Declarations. Ethics approval and consent to participate: Not Applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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