Astrocytic inhibition of lateral septal neurons promotes diverse stress responses.

Autor: Seo K; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Won S; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Lee HY; Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea., Sin Y; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Lee S; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea.; Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Park H; Laboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Kim YG; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Yang SY; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Kim DJ; Laboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Suk K; Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, Kyungpook National University, Daegu, Republic of Korea., Koo JW; Emotion, Cognition and Behavior Research Group, Korea Brain Research Institute (KBRI), Daegu, Republic of Korea., Baek M; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea., Choi SY; Department of Physiology and Neuroscience, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea. sychoi@snu.ac.kr., Lee H; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea. hyosang22@dgist.ac.kr.; Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu, Republic of Korea. hyosang22@dgist.ac.kr.; Korea Brain Research Institute (KBRI), Daegu, Republic of Korea. hyosang22@dgist.ac.kr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Nov 21; Vol. 15 (1), pp. 10091. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1038/s41467-024-54376-x
Abstrakt: Inhibitory neuronal circuits within the lateral septum (LS) play a key role in regulating mood and stress responses. Even though glial cells can modulate these circuits, the impact of astrocytes on LS neural circuits and their functional interactions remains largely unexplored. Here, we demonstrate that astrocytes exhibit increased intracellular Ca²⁺ levels in response to aversive sensory and social stimuli in both male and female mice. This astrocytic Ca²⁺ elevation inhibits neighboring LS neurons by reducing excitatory synaptic transmissions through A 1 R-mediated signaling in both the dorsal (LSd) and intermediate LS (LSi) and enhancing inhibitory synaptic transmission via A 2A R-mediated signaling in the LSi. At the same time, astrocytes reduce inhibitory tone on distant LS neurons. In the LSd, astrocytes promote social avoidance and anxiety, as well as increased heart rate in socially stressed male mice. In contrast, astrocytes in the LSi contribute to elevated heart rate and heightened blood corticosterone levels in unstressed male mice. These results suggest that the dynamic interactions between astrocytes and neurons within the LS modulate physiological and behavioral responses to stressful experiences.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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