Mapping epilepsy biomarkers: a bibliometric and content analysis.

Autor: Ngadimon IW; Neuroscience Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia. Electronic address: irmawati.ngadimon@monash.edu., Shaikh MF; Neuroscience Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia; School of Dentistry and Medical Sciences, Charles Sturt University, Australia. Electronic address: farooq.shaikh@monash.edu., Mohan D; Global Public Health, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia; School of Public Health, The University of Queensland, Brisbane, Australia., Cheong WL; School of Pharmacy, Monash University Malaysia, Selangor, Malaysia., Khoo CS; Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; Neurology Unit, Department of Medicine, Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Malaysia; Centre for Global Epilepsy, Wolfson College, University of Oxford, Oxford, United Kingdom.
Jazyk: angličtina
Zdroj: Drug discovery today [Drug Discov Today] 2024 Dec; Vol. 29 (12), pp. 104247. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1016/j.drudis.2024.104247
Abstrakt: Epilepsy, a complex global neurological disorder, has spurred extensive research efforts focused on enhancing diagnostic and therapeutic strategies, with a growing emphasis on the identification of biomarkers. This bibliometric study examines 1,774 publications from 2000 to 2023, revealing a notable increase in research activity, particularly in the past decade. The US, China, and the UK lead contributions, with Asian countries exhibiting growing potential. Keyword co-occurrence analysis reveals a shift towards investigations of neuroinflammatory and genetic biomarkers, as well as emerging areas such as artificial intelligence and epigenetics. Content analysis links specific epilepsy aetiologies to biomarkers, offering promising possibilities for personalised diagnostics and treatments. These findings yield valuable insights into current trends, guiding future research and informing the development of targeted approaches for the diagnosis and treatment of epilepsy.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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