NREM sleep improves behavioral performance by desynchronizing cortical circuits.

Autor: Kharas N; Department of Neurological Surgery, Weill Cornell Medical School, New York, NY, USA.; Department of Physiology and Biophysics, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA., Chelaru MI; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas-Houston, Houston, TX, USA., Eagleman S; Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas-Houston, Houston, TX, USA.; Department of Anesthesiology, Stanford School of Medicine, Palo Alto, CA, USA., Parajuli A; Department of Neurological Surgery, Weill Cornell Medical School, New York, NY, USA., Dragoi V; Department of Physiology and Biophysics, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA.; Center for Neural Systems Restoration, Houston Methodist Research Institute, Houston, TX, USA.; Neuroengineering Initiative, Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2024 Nov 22; Vol. 386 (6724), pp. 892-897. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1126/science.adr3339
Abstrakt: Sleep improves cognitive performance, yet little is known about the neural mechanisms of this improvement. We performed multielectrode recording in macaque visual and dorsolateral prefrontal cortex while animals performed a visual discrimination task before and after non-rapid eye movement (NREM) sleep. Although sleep induces synchronized fluctuations in population activity across cortical areas, the post-sleep population activity became more desynchronized relative to the pre-sleep state. The changes after sleep were correlated with an increase in information encoded in population activity in each area and improved behavioral performance. Electrically stimulating visual cortex at 4 hertz emulated the beneficial effects of sleep on network and perceptual performance. A large-scale neural network model indicated that asymmetric depression of local intracortical synapses is consistent with the observed changes in neural activity after sleep.
Databáze: MEDLINE
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