Organoid models of breast cancer in precision medicine and translational research.

Autor: Niazi V; Stem Cell Research Center, Golestan University of Medical Science, Gorgan, Iran.; School of Advanced Technologies in Medicine, Golestan University of Medical Science, Shastkola Street, Gorgan, 4918936316, Iran., Parseh B; Stem Cell Research Center, Golestan University of Medical Science, Gorgan, Iran. benyamin_parseh@yahoo.com.; School of Advanced Technologies in Medicine, Golestan University of Medical Science, Shastkola Street, Gorgan, 4918936316, Iran. benyamin_parseh@yahoo.com.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Nov 21; Vol. 52 (1), pp. 2. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1007/s11033-024-10101-x
Abstrakt: One of the most famous and heterogeneous cancers worldwide is breast cancer (BC). Owing to differences in the gene expression profiles and clinical features of distinct BC subtypes, different treatments are prescribed for patients. However, even with more thorough pathological evaluations of tumors than in the past, available treatments do not perform equally well for all individuals. Precision medicine is a new approach that considers the effects of patients' genes, lifestyle, and environment to choose the right treatment for an individual patient. As a powerful tool, the organoid culture system can maintain the morphological and genetic characteristics of patients' tumors. Evidence also shows that organoids have high predictive value for patient treatment. In this review, a variety of BC studies performed on organoid culture systems are evaluated. Additionally, the potential of using organoid models in BC translational research, especially in immunotherapy, drug screening, and precision medicine, has been reported.
Competing Interests: Declarations. Research involving human and animal rights: This study does not involve human participants or animals. Informed consent: As there was no direct patient data acquisition for this study, no informed consent was required or obtained [8]. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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