Infectious morbidity and white blood cell count associated with grade repetition and school absenteeism.

Autor: Villamor E; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA., Beer RJ; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA., Seeley AL; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA., López-Arana S; Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile., Marín C; Facultad de Medicina, Universidad de La Sabana, Chía, Colombia., Mora-Plazas M; Foundation for Research in Nutrition and Health, Bogotá, Colombia.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1111/apa.17513
Abstrakt: Aim: Infections can impair cognitive development, but their role on adverse childhood educational outcomes is unknown. We examined the associations of infectious morbidity and inflammatory biomarkers with grade repetition and school absenteeism.
Methods: We followed 2762 Colombian children aged 5-12 years for a school year. We quantified inflammatory biomarkers at enrolment and prospectively recorded incidence of gastrointestinal and respiratory infections, doctor visits and absent days from school using pictorial diaries. We estimated adjusted relative risks (ARR) with 95% confidence intervals (CI) for grade repetition and absenteeism by infectious morbidity burden and inflammatory biomarker categories, and percentages of the associations mediated through absenteeism.
Results: Morbidity was associated with increased risk of grade repetition. ARR (95% CI) of grade repetition comparing high versus no incidence of gastrointestinal, respiratory and ear infections were, respectively, 2.17 (1.00, 4.72), 2.31 (1.28, 4.16) and 2.57 (1.13, 5.86). Infections also predicted school absenteeism, which mediated 35%, 31% and 38% of the corresponding morbidity-grade repetition associations. Elevated white blood cells (WBC), especially granulocytes, were related to increased grade repetition and school absenteeism risks.
Conclusion: Childhood infections and elevated WBC are associated with grade repetition and school absenteeism. Absenteeism does not fully explain the morbidity-grade repetition associations.
(© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
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