Hemolytic Anemia Secondary to Rasburicase Treatment in the Setting of Glucose-6-Phosphate-Dehydrogenase Deficiency: A Case Report.
| Autor: | Stone JC; Internal Medicine, Northwell Health, New Hyde Park, USA., Santhosh S; Internal Medicine, Northwell Health, New Hyde Park, USA., Paracha A; Internal Medicine, Northwell Health, New Hyde Park, USA., Kwait B; Internal Medicine, Northwell Health, New Hyde Park, USA., John V; Hematology and Medical Oncology, Northwell Health, New Hyde Park, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Oct 21; Vol. 16 (10), pp. e72024. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.72024 |
| Abstrakt: | Rasburicase is a recombinant form of urate oxidase, a medication used to treat hyperuricemia by metabolizing uric acid into an inactive and more soluble metabolite, allantoin. An oxidizing agent, hydrogen peroxide, is produced during the conversion of uric acid to allantoin. We present here a case of hemolytic anemia secondary to rasburicase treatment which was later confirmed to have glucose-6-phosphate dehydrogenase deficiency (G6PDD). Treatment was stopped after one dose and the patient received a transfusion of packed red blood cells to correct the anemia. The patient's hyperuricemia was subsequently managed with allopurinol and febuxostat. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Stone et al.) |
| Databáze: | MEDLINE |
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