Case report: Infectious mononucleosis with bilateral retinal haemorrhages under myelin oligodendrocyte glycoprotein antibody-associated disease.

Autor:	Li Y; Senior Department of Ophthalmology, the Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital & Chinese PLA Medical School, Beijing, China., Sun M; Senior Department of Ophthalmology, the Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital & Chinese PLA Medical School, Beijing, China., Wei S; Senior Department of Ophthalmology, the Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital & Chinese PLA Medical School, Beijing, China., Xu Q; Senior Department of Ophthalmology, the Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital & Chinese PLA Medical School, Beijing, China., Zhou H; Senior Department of Ophthalmology, the Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital & Chinese PLA Medical School, Beijing, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Nov 06; Vol. 15, pp. 1480134. Date of Electronic Publication: 2024 Nov 06 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1480134
Abstrakt:	Background: Bilateral optic neuritis associated with optic disc swelling is a common feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). However, extensive deep retinal haemorrhages have not been described in the context of MOG-associated optic neuritis. Here, we report a case of infectious mononucleosis with marked binocular peripapillary and perivascular haemorrhages as well as extensive deep retinal haemorrhages in the presence of MOGAD. Case Report: A 39-year-old Chinese woman presenting with subacute binocular vision reduction with no light perception was diagnosed with MOGAD. Fundus examination revealed the presence of binocular peripapillary and perivascular haemorrhages as well as extensive deep retinal haemorrhages with severe optic disc swelling greater in the right eye than in the left and dilated and tortuous retinal venules. The patient tested positive for the Epstein-Barr virus (EBV) antigen (595 U/mL) and the EBV capsid antigen (>750 U/mL). She had a fever and right upper quadrant abdominal pain, and a doctor determined splenomegaly 1 week before the onset of orbital pain and decreased vision acuity. Medical history and laboratory tests indicated the presence of concurrent infectious mononucleosis. Other investigational indicators of retinal haemorrhages, including hypertension, diabetes mellitus, vascular disease, systemic lupus erythematosus, metabolic disease, and renal or liver dysfunction, were absent. Discussion: This case suggests that retinal haemorrhage is a possible complication of infectious mononucleosis in the presence of MOGAD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Li, Sun, Wei, Xu and Zhou.)
Databáze:	MEDLINE
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