Cytokine signatures in post-endoscopic retrograde cholangiopancreatography pancreatitis: a pilot study.

Autor:	Machicado JD; Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI (Jorge D. Machicado)., Lee PJ; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH (Peter J. Lee, Phil A. Hart, Mitchell Ramsey, Georgios I. Papachristou)., Culp S; Department of Biomedical Informatics, The Ohio State University, Columbus, OH (Stacey Culp)., Stello K; Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA (Kimberly Stello)., Hart PA; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH (Peter J. Lee, Phil A. Hart, Mitchell Ramsey, Georgios I. Papachristou)., Ramsey M; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH (Peter J. Lee, Phil A. Hart, Mitchell Ramsey, Georgios I. Papachristou)., Lacy-Hulbert A; Benaroya Research Institute at Virginia Mason, Seattle, Washington (Adam Lacy-Hulbert, Cate Speake)., Speake C; The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH (Zobeida Cruz-Monserrate)., Cruz-Monserrate Z; Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC (B. Joseph Elmunzer)., Elmunzer BJ; Ariel Precision Medicine (David C. Whitcomb)., Whitcomb DC; Department of Physiology & Molecular Physiology, University of Pittsburgh, Pittsburgh, PA (David C. Whitcomb).; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA (David C. Whitcomb)., Papachristou GI; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH (Peter J. Lee, Phil A. Hart, Mitchell Ramsey, Georgios I. Papachristou).
Jazyk:	angličtina
Zdroj:	Annals of gastroenterology [Ann Gastroenterol] 2024 Nov-Dec; Vol. 37 (6), pp. 734-741. Date of Electronic Publication: 2024 Oct 23.
DOI:	10.20524/aog.2024.0922
Abstrakt:	Background: Following endoscopic retrograde cholangiopancreatography (ERCP), post-ERCP pancreatitis (PEP) is the most common complication. The host's innate immune response to periprocedural pancreatic injury is the hallmark of its pathogenesis. Investigating cytokine signatures associated with PEP and its risk factors can guide understanding of PEP immunopathogenesis. Methods: We conducted a single-center, prospective, observational pilot study in adults at high-risk for PEP. Seven serum cytokines relevant to early acute pancreatitis pathogenesis, angiopoietin-2, hepatocyte growth factor (HGF), interleukin-6 (IL-6), IL-8, monocyte chemotactic protein-1, resistin, and soluble tumor necrosis factor-α receptor 1, were measured in sera collected 2 h pre- and post-ERCP. Levels were compared among healthy controls and ERCP participants who either did or did not develop PEP. Heat maps were constructed to perform a multidimensional exploratory analysis that aimed to determine the cytokine signatures associated with PEP and its participant-related risk factors (female sex, young age, and obesity). Results: A total of 65 participants were enrolled (36 undergoing ERCP and 29 healthy controls). Eight of the 36 (22.2%) ERCP participants developed PEP. Baseline IL-8 levels measured before ERCP were elevated in participants who developed PEP (7.5 vs. 14.8 pg/mL, P=0.02), and most strongly upregulated in women under 40 years of age. HGF levels post-ERCP were higher in participants with PEP (738.0 vs. 556.6 pg/mL, P=0.04), and most strongly upregulated in obese participants. Conclusions: Pre-ERCP IL-8 and post-ERCP HGF are associated with the development of PEP. Findings from this pilot study can inform the design of translational work in the immunopathogenesis of PEP. Competing Interests: Conflict of Interest: None (Copyright: © 2024 Hellenic Society of Gastroenterology.)
Databáze:	MEDLINE
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