Addressing the Peri-Wound Intact Skin of Hard-To-Heal Diabetic Foot Ulcers With Topical Red Deer Conditioned Media (PTT-6 TM ) Skin Conditioner: A Case Series on Clinical Efficacy.

Autor: Leow K; Department of Podiatry Sengkang General Hospital Singapore., Alvis LTC; Department of Podiatry Sengkang General Hospital Singapore., Yuen BEC; Department of Podiatry Sengkang General Hospital Singapore., Cheng L; Department of Podiatry Sengkang General Hospital Singapore., Chiam S; Department of Podiatry Sengkang General Hospital Singapore., Razak SNBA; Department of Podiatry Sengkang General Hospital Singapore., Evans GB; Department of Podiatry Sengkang General Hospital Singapore., Koh K; Department of Podiatry Sengkang General Hospital Singapore., Lim IJ; CellResearch Corporation Singapore Singapore., Phan TT; CellResearch Corporation Singapore Singapore., Wong KL; Department of Orthopaedic Surgery Sengkang General Hospital Singapore Singapore.; Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.; Musculoskeletal Sciences Academic Clinical Programme Duke-NUS Medical School Singapore Singapore.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2024 Nov 20; Vol. 7 (11), pp. e70211. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).
DOI: 10.1002/hsr2.70211
Abstrakt: Background and Aim: The healing of diabetic foot ulcers (DFUs) can be hindered by the susceptibility of the surrounding intact skin to pro-inflammatory proteases. A conditioned media, known as PTT-6 TM , derived from mesenchymal stem cells found in the lining of red deer umbilical cords, has been formulated to protect the intact peri-wound skin of DFUs. The aim is to evaluate the clinical effectiveness of PTT-6 TM in managing peri-wound intact skin in hard-to-heal DFUs.
Methods: Patients with DFUs that persisted for over 3 months were divided into two subgroups. The active wound group received standard-of-care treatment protocol followed by PTT-6 TM application around the peri-wound area, while the maintenance wound group applied PTT-6 TM media over the healed wound site.
Results: Forty cases were recorded, of which 22 (55%) were included in the active wound group. The majority were male (75%, n  = 30) and vast majority had cardiovascular risk factors, including diabetes mellitus (100%, n  = 40), hyperlipidemia (82.5%, n  = 33), and hypertension (77.5%, n  = 31). Most patients had forefoot wounds (80%, n  = 32) on the plantar aspect (82.5%, n  = 33). The patients in the active wound group had chronic DFUs for a mean of 218 ± 201 days. Of those treated with PTT-6™ media, 68.4% ( n  = 13) achieved complete wound healing within a mean duration of 69 ± 50 days. Additionally, most patients in the maintenance wound group remained ulcer-free at 3 months (91.7%, n  = 11) and 6 months (66.7%, n  = 6).
Conclusion: The study results suggest that PTT-6 TM media may serve as an additional treatment modality for enhancing the microenvironment at the peri-wound intact skin site. This could indirectly facilitate wound healing by preserving the integrity of the peri-wound intact skin.
Competing Interests: Keng Lin Wong receives honorarium as a speaker for CellResearch Corporation, 3M‐KCI Medical Asia Pte. Ltd., Urgo Medical APAC, and Molnlycke Health Care Asia‐Pacific Pte. Ltd. Ivor Jiun Lim and Toan Thang Phan are associated with CellResearch Corporation, which is known to own intellectual properties related to Cord Lining Stem Cells technology and is a provider of PTT‐6TM for the study. The two authors state that the manuscript was written without any undue influence from them and without any attempt to inject opinions that will benefit the technology. The other authors declare no conflicts of interest.
(© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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