Berberine and Lung Cancer: From Pure Form to Its Nanoformulations.

Autor:	Tamtaji Z; Student Research Committee, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Sheikhsagha E; Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland., Behnam M; Student Research Committee, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Nabavizadeh F; Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran., Shafiee Ardestani M; Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran., Rahmati-Dehkordi F; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA., Mirzaei H; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran., Tamtaji OR; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Jazyk:	angličtina
Zdroj:	Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.
DOI:	10.1111/ajco.14134
Abstrakt:	Lung cancer is the most fatal cancer worldwide. The etiology of lung cancer has yet to be fully characterized. Smoking and air pollution are several risk factors for lung cancer. Berberine, an isoquinoline alkaloid, is an antihyperglycemic, antidepressant, antioxidative, anti-inflammatory, and anticancer compound. Evidence substantiates that berberine has antitumor effects, exerting its effects by targeting a variety of cellular and molecular processes, such as apoptosis, autophagy, cell cycle arrest, migration, and metastasis. Although the beneficial effects of berberine have been reported, some limitations including low bioavailability and absorption as well as poor aqueous solubility have hindered its clinical application. Nanotechnology and nanodelivery bioformulation approaches may bypass these limitations. In addition, the combination of berberine with other therapies has been shown to result in greater treatment efficacy for lung cancer. Herein, we summarize cellular and molecular pathways that are affected by berberine, its clinical efficacy upon various combinations, and the potential for nanotechnology in lung cancer therapy. (© 2024 John Wiley & Sons Australia, Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Plný text