Clinical validation on role of cancer diagnostic probe in detecting the involved cavity margins missed in permanent pathology of tumor side in breast cancer surgery.

Autor: Abbasvandi F; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran.; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran.; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Miripour ZS; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran., Bayat M; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran.; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mousavi-Kiasary SMS; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran., Shayanfar S; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shojaeian F; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran.; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Aghaei F; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran., Jahanbakhshi F; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran., Abbasvandi N; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran.; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran., Omranihashemi M; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akbari A; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Yousefi M; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hadizadeh M; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran., Farahani NS; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hosseinpoor P; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran.; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran.; SEPAS Pathology Laboratory, Tehran, Iran., Parniani M; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran., Nourinjad Z; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran., Abdolahad M; Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran. m.abdolahad@ut.ac.ir.; Cancer Institute, Imam-Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. m.abdolahad@ut.ac.ir., Akbari ME; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Diagnostic pathology [Diagn Pathol] 2024 Nov 20; Vol. 19 (1), pp. 148. Date of Electronic Publication: 2024 Nov 20.
DOI: 10.1186/s13000-024-01574-2
Abstrakt: Cancer diagnostic probe (CDP) as a newly entered tool in real-time breast cavity margin evaluation showed great improvement in smart margin shaving intra-operatively. This system increased the rate of involved margin detection to 30% with respect to frozen section. In this study for the first time we showed the independent role of CDP in finding the involved cavity side margins which were not diagnosed by permananet pathology of their tumor side interface. Among 147 detected margins by CDP, 23 lesions with invasive component and ductal carcinoma in-situ/ductal cancerization weren't reported as involved margins in permanent pathology of tumor side. Our gold standard was the histology of cavity margin specimen had been scored as involved lesion by CDP. It seems that even when the permanent pathology of surgical margins is used for final declaration, role of CDP is irreplaceable. This distinguished achievement has been obtained intra-operatively in real-time by CDP while involved report in permanent pathology of tumor margins induce re-surgery for the patient.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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