Pre- and post-polyphenol intake and ovarian cancer survival: evidence from a prospective cohort study.
| Autor: | Sun JN; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China., Li Y; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China., Luan M; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China., Wu L; Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA., Liu FH; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China., Li YZ; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China., Xu HL; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China., Wei YF; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China., Xiao Q; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.; Hospital Management Office, Shengjing Hospital of China Medical University, Shenyang, China., Li XY; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China., Xu J; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China., Liu KX; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China., Huang DH; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. huangdh@sj-hospital.org.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. huangdh@sj-hospital.org., Wu QJ; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org.; Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org.; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China. wuqj@sj-hospital.org.; NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University), National Health Commission, Shenyang, China. wuqj@sj-hospital.org., Gong TT; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. gongtt@sj-hospital.org. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | European journal of nutrition [Eur J Nutr] 2024 Nov 21; Vol. 64 (1), pp. 14. Date of Electronic Publication: 2024 Nov 21. |
| DOI: | 10.1007/s00394-024-03516-6 |
| Abstrakt: | Purpose: Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions. Methods: The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival. Dietary intakes of total (poly)phenols and their five classes (flavonoids, phenolic acids, lignans, stilbenes, and other polyphenols) were assessed using a validated 111-item food frequency questionnaire. Overall survival (OS) was tracked through active follow-up and medical records until February 16th, 2023. Cox proportional hazard regression models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI). Results: During a median follow-up of 44.4 months, 211 all-cause deaths were identified. We observed significant associations between higher polyphenol intake with lower risk of mortality among patients with OC ((HR Conclusion: Dietary (poly)phenols, as well as its five classes, have an inverse association with OC survival. Competing Interests: Declarations. Ethics approval and consent to participate: The OOPS was approved by the Institutional Review Board of the Ethics Committee of Shengjing Hospital of China Medical University. All participants signed informed consent. Competing interests: The authors declare that they have no conflict of interest. (© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink