Why are RNA processing factors recruited to DNA double-strand breaks?

Autor: Machour FE; Department of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel., Barisaac AS; Department of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel., Ayoub N; Department of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel. Electronic address: ayoubn@technion.ac.il.
Jazyk: angličtina
Zdroj: Trends in genetics : TIG [Trends Genet] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1016/j.tig.2024.10.008
Abstrakt: DNA double-strand break (DSB) induction leads to local transcriptional silencing at damage sites, raising the question: Why are RNA processing factors (RPFs), including splicing factors, rapidly recruited to these sites? Recent findings show that DSBs cluster in a chromatin compartment termed the 'D compartment', where DNA damage response (DDR) genes relocate and undergo transcriptional activation. Here, we propose two non-mutually exclusive models to elucidate the rationale behind the recruitment of RPFs to DSB sites. First, RPFs circulate through the D compartment to process transcripts of the relocated DDR genes. Second, the D compartment serves as a 'post-translational modifications (PTMs) hub', altering RPF activity and leading to the production of unique DNA damage-induced transcripts, which are essential for orchestrating the DDR.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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