Assessing the Effects of Palm Oil Consumption on Life Expectancy, Metabolic Markers, and Oxidative Stress in Drosophila melanogaster.

Autor: da Silva GF; Oxidative Stress and Cell Signaling Research Group, Federal University of Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul, Brazil., Rodrigues NR; Research Group of Biochemistry and Toxicology of Bioactive Compounds (GBToxBio), Federal University of Pampa, Campus Uruguaiana, Uruguaiana, Rio Grande do Sul, Brazil., Boligon AA; Post-Graduation Program in Pharmaceutical Sciences, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Ávila E; Oxidative Stress and Cell Signaling Research Group, Federal University of Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul, Brazil., da Rosa Silva L; Oxidative Stress and Cell Signaling Research Group, Federal University of Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul, Brazil., Franco JL; Oxidative Stress and Cell Signaling Research Group, Federal University of Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul, Brazil., Posser T; Oxidative Stress and Cell Signaling Research Group, Federal University of Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Cell biochemistry and function [Cell Biochem Funct] 2024 Dec; Vol. 42 (8), pp. e70017.
DOI: 10.1002/cbf.70017
Abstrakt: Palm oil is the world's second most consumed vegetable oil, sourced from the tropical palm tree Elaeis guineensis. Its consumption has been associated with a higher incidence of cardiovascular disease, largely due to its elevated palmitic acid content, however those studies are contradictory and inconclusive. Wishing to contribute to this issue, the present study aims to investigate the molecular and toxicological effects of this oil and the involvement of oxidative stress, given its role in metabolic dysfunctions using Drosophila melanogaster. This study examines survival rates, and locomotor performance, oxidative status by analysis of lipid peroxidation, ROS formation, thiol levels and antioxidant enzyme activity, and metabolic parameters such as cholesterol and triglycerides, glucose, trehalose and glycogen levels. Exposure to palm oil concentrations of 10% and 30% resulted in a shortened lifespan, reduced locomotor performance, and increased lipid peroxidation, with lower thiol levels and antioxidant enzyme modulation. Cholesterol levels was increased whereas energetic fuels as glucose and glycogen and trehalose were decreased mainly after 10 days of exposure. These findings underscore the detrimental effects of high-fat diets containing palm oil on lifespan, antioxidant defenses, and metabolism in Drosophila melanogaster. This data highlights the potential risk associated with the habitual consumption of palm oil in the daily diet by population, particularly concerning cardiovascular health and metabolic function.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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