Clinical and histomorphometric evaluation of the vagina following treatment with CO 2 laser, radiofrequency, and promestriene for genitourinary syndrome of menopause in breast cancer survivors on adjuvant therapy.
| Autor: | Cantarelli GC; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Bianchi-Ferraro AMHM; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil. Electronic address: z.bella@unifesp.br., Dedonatto C; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Fernandes MFR; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Vanzin RB; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Dardes RCM; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Logullo AF; Department of Pathology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., de Almeida JS; Department of Pathology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Facina G; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., de Jármy-Di Bella ZIK; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Sartori MGF; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil., Patriarca MT; Department of Gynecology, Federal University of São Paulo - Paulista Medical School, UNIFESP/EPM, São Paulo, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Maturitas [Maturitas] 2025 Jan; Vol. 191, pp. 108155. Date of Electronic Publication: 2024 Nov 14. |
| DOI: | 10.1016/j.maturitas.2024.108155 |
| Abstrakt: | Purpose: To perform clinical and histomorphometric evaluations of the vagina before and after treatment for genitourinary syndrome of menopause with CO Methods: The study included women experiencing moderate to severe genitourinary syndrome of menopause. Following pre- and post-treatment protocols, participants graded their symptoms on a visual analog scale and underwent a gynecological examination to evaluate the Vaginal Health Index and obtain a vaginal biopsy. Subsequently, they were randomized to laser, radiofrequency, and promestriene groups. The energy groups underwent three consecutive monthly outpatient vulvovaginal treatments, while the control group received promestriene treatment for four months, followed by a post-treatment evaluation. Results: Sixty-two women completed the study protocol (21 laser, 20 radiofrequency, and 21 promestriene). While histological differences (vaginal thickness [p = 0.002] and number of stromal papillae [p = 0.004]) were observed between the pretreatment samples of tamoxifen and anastrozole users, the symptoms did not differ between them. A decrease in symptom intensity (p < 0.05) and an improvement in the Vaginal Health Index (p < 0.001) were observed post-treatment, regardless of the type of adjuvant endocrine therapy used. Most pretreatment vaginal samples did not indicate histological atrophy, and no significant histological differences were observed after treatment. No clinical or histological damage was observed. Conclusion: CO Trial Registration Number: NCT04081805. Competing Interests: Declaration of competing interest The authors declare that they have no competing interest. (Copyright © 2024. Published by Elsevier B.V.) |
| Databáze: | MEDLINE |
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