Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers.

Autor: Rijns L; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands., Rutten MGTA; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands., Bellan R; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands., Yuan H; Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, P.O. Box 2404, B3001 Leuven, Flanders, Belgium.; Key Laboratory of Molecular Biophysics of Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300401, P.R. China., Mugnai ML; Institute for Soft Matter Synthesis and Metrology, Department of Physics, Georgetown University, Washington, D.C. 20057, USA., Rocha S; Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, P.O. Box 2404, B3001 Leuven, Flanders, Belgium., Del Gado E; Institute for Soft Matter Synthesis and Metrology, Department of Physics, Georgetown University, Washington, D.C. 20057, USA., Kouwer PHJ; Radboud University, Institute for Molecules and Materials, P.O. Box 9010, 6525 AJ Nijmegen, Netherlands., Dankers PYW; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.; Department of Biomedical Engineering, Laboratory of Chemical Biology, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.; Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, Netherlands.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Nov 22; Vol. 10 (47), pp. eadr3209. Date of Electronic Publication: 2024 Nov 20.
DOI: 10.1126/sciadv.adr3209
Abstrakt: Nature uses discrete molecular building blocks to form polymers that assemble into multicomponent, multi-dynamic networks, inside (cytoskeleton) and outside (extracellular matrix) the cell. Both the intra-fibrous molecular dynamics and interactions between fibers dictate (non)linear mechanics, such as stress stiffening and relaxation, and ultimately biological function. Current synthetic systems capture only one dynamic process. Here, we present multi-dynamic hydrogels by uniting a stress-stiffening polymer with supramolecular polymers. Crucial is the molecular dynamics of the supramolecular polymers: They dictate the interaction strength with the stress-stiffening polymer and the subsequent dynamic mechanical properties of the mixed networks. The biological relevance of our multi-dynamic hydrogels is demonstrated by their ability to support fibroblast cell spreading. Future work may address the display of various dynamically presented bioactive cues to cells.
Databáze: MEDLINE