Tailored Bioengineering and Nanomedicine Strategies for Sex-Specific Healing of Chronic Wounds.

Autor:	Mahmoudi N; The Graeme Clark Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Melbourne, VIC 3010, Australia., Sharifi S; Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States., Leshchiner D; Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States., Horibata S; Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824, United States.; Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan 48824, United States., Lin Z; Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States., Ghazali N; The Graeme Clark Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Shahbazi MA; Department of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands., Priyam A; IMPACT, School of Medicine, Deakin University, Geelong, VIC 3217, Australia., Williams RJ; The Graeme Clark Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.; IMPACT, School of Medicine, Deakin University, Geelong, VIC 3217, Australia., Pastar I; Dr Phillip Frost Dept. of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, United States., Gould L; Warren Alpert Medical School of Brown University, Providence, Rhode Island 02912, United States.; South Shore Health Center for Wound Healing, Weymouth, Massachusetts 02189, United States., Matoori S; Faculté de Pharmacie, Université de Montréal, Montreal, Quebec, Canada., Nisbet D; The Graeme Clark Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.; Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Melbourne, VIC 3010, Australia.; Melbourne Medical School, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, VIC 3010, Australia., Mahmoudi M; Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.; Connors Center for Women's Health & Gender Biology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115  USA.
Jazyk:	angličtina
Zdroj:	The British journal of dermatology [Br J Dermatol] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.
DOI:	10.1093/bjd/ljae457
Abstrakt:	Chronic wounds, defined by their prolonged healing process, significantly impair patient quality of life and impose a hefty financial burden on healthcare systems worldwide. Sex/gender-specific mechanisms regulate inflammation and infection, angiogenesis, matrix synthesis, and cell recruitment contribute to cutaneous wound healing, but remain largely understudied. This review is aimed to spotlight the innovative realm of bioengineering and nanomedicine, which is at the helm of revolutionizing complex chronic wound care. It underscores the significance of integrating patient sex into the development and (pre)clinical testing of these avant-garde treatment modalities, in order to enhance healing prospects for both women and men. Moreover, we explore the representation of both sexes in clinical trials of bioengineered and nanomedicine products. Finally, we examine the primary reasons for the historical neglect in translating sex-specific wound healing research into clinical practice and propose strategic solutions. By tackling these issues, the article advocates for advanced treatment frameworks that could significantly improve healing outcomes for individuals of all sexes, thereby optimizing both efficacy and inclusivity in chronic wound management. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists.)
Databáze:	MEDLINE
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