SLE inflammatory musculoskeletal abnormalities, confirmed by MRI, show a specific profile with a worse health-related quality of life.

Autor: Corzo P; Rheumatology Department, Hospital Clínic de Barcelona, Barcelona, Spain., Agustí Claramunt A; Musculoskeletal Radiology Department, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Garcia-Duitama I; Musculoskeletal Radiology Department, Hospital QuironSalud, Barcelona, Spain., Carrión-Barberá I; Rheumatology Department, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Marsico S; Musculoskeletal Radiology Department, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Duran Jordà X; AMIB - Assessoria Metodològica i Bioestadística, IMIM, Barcelona, Spain., Monfort Faure J; Rheumatology Department, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain., Salman-Monte TC; Rheumatology Department, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2024 Nov 20, pp. 9612033241301515. Date of Electronic Publication: 2024 Nov 20.
DOI: 10.1177/09612033241301515
Abstrakt: Objectives: To determine if there is a clinicodemographic or serological profile associated with MRI-confirmed inflammatory musculoskeletal abnormalities in SLE patients. To investigate the relationship between these alterations and HRQoL.
Methods: patients with SLE from our previous study in whom a wrist and hand MRI with contrast was performed were included. Sociodemographic, clinical, therapeutic, serological data and PROs were collected and correlated with MRI findings.
Results: 83 patients were analysed. Erosions and synovitis were more common in older patients (55 ± 12.61 vs 45.06 ± 12.18 years, p .001, 52.78 ± 12.99 vs 44.95 ± 12.49 years, p .011). Synovitis was less frequent in patients with nephritis (6.7% vs 24.3%, p .031). Treatment received showed some associations: patients with bone edema received more methotrexate (25% vs 6.3%, p .033), those with erosions and peritendonitis received less mycophenolic acid (5.6% vs 22.9%, p .034; 0% vs 12.8%, p .026). Peritendonitis correlated with higher SLEDAI-2K (7 ± 2.45 vs 3.64 ± 3.34, p .018).
Worse Haq: Patients with synovitis, tenosynovitis, peritendonitis and bone edema reported higher pain (6.03 ± 2.57 vs 4.26 ± 2.49, p .005; 6.56 ± 1.95 vs 4.76 ± 2.75, p .017; 8.80 ± 1.30 vs 4.95 ± 2.55, p .001; 6.47 ± 2.62 vs 4.83 ± 2.58, p .026, respectively). Patients with synovitis reported higher fatigue numerical values (2.32 ± 0.82 vs 1.91 ± 0.84, p .035), with tenosynovitis worse FSS-9 (61.50 ± 1.73 vs 45.70 ± 16.80, p .015), and with both synovitis and peritendonitis worse HAQ (1.14 ± 0.69 vs 0.75 ± 0.65, p .031; 1.69 ± 0.07 vs 0.90 ± 0.69, p .018).
Conclusion: SLE patients with confirmed musculoskeletal alterations on MRI were generally older, less likely to have lupus nephritis, and received different treatments. They reported a worse HRQoL in terms of pain, fatigue and functional disability.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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