| Autor: |
Machado FP; Natural Products Technology Laboratory (LTPN), Pharmacy Faculty, Fluminense Federal University, Niterói, Brazil.; Postgraduate Program in Applied Science for Health Products, Faculty of Pharmacy, Fluminense Federal University, Niteroi, Brazil., Wermelinger GF; Basic Science Department, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., Canuto ASCL; Postgraduate Program in Applied Science for Health Products, Faculty of Pharmacy, Fluminense Federal University, Niteroi, Brazil., Fonseca ACCD; Postgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil., Folly D; Natural Products Technology Laboratory (LTPN), Pharmacy Faculty, Fluminense Federal University, Niterói, Brazil.; Postgraduate Program in Plant Biotechnology and Bioprocesses, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Arruda ATS; Postgraduate Program in Morphological Sciences, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Rocha L; Natural Products Technology Laboratory (LTPN), Pharmacy Faculty, Fluminense Federal University, Niterói, Brazil., Robbs BK; Basic Science Department, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Brazil. |
| Abstrakt: |
Cancer is a global public health problem, requiring the development of new and more effective drugs for treatment. Eremanthus crotonoides , is a common plant found in the Brazilian Cerrado and Atlantic Forest and is used as a traditional medicinal plant in some regions. This study evaluated the potential antitumor effect of centratherin, a compound isolated from E. crotonoides leaves, against cancer cells. In colorectal cancer cells, centratherin showed greater toxicity than carboplatin while maintaining comparable selectivity to the control. Although centratherin did not induce classical apoptotic phenotypes and was not inhibited by Zvad, it did induce elevated levels of reactive oxygen species (ROS) that was responsible for cell death explaining its toxicity. in silico analysis, showed that this substance has high oral bioavailability and intestinal absorption. Centratherin was found to be selective against colon cancer cells and, therefore may be considered for future studies on colorectal cancer (CRC) studies. |
