Autologous Epstein-Barr virus-specific adoptive T-cell therapy in a patient with lupus nephritis.

Autor: Ranganathan D; Kidney Health Service Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service Herston QLD Australia.; School of Medicine and Dentistry Griffith University Southport QLD Australia., Leibowitz S; Kidney Health Service Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service Herston QLD Australia., John GT; Kidney Health Service Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service Herston QLD Australia.; Faculty of Medicine University of Queensland Herston QLD Australia., Neller MA; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Ambalathingal GR; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Beagley L; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Panikkar A; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Best S; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Raju J; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Reddiex H; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Ratanjee S; Kidney Health Service Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service Herston QLD Australia.; Faculty of Medicine University of Queensland Herston QLD Australia., Ng MSY; Kidney Health Service Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service Herston QLD Australia.; Faculty of Medicine University of Queensland Herston QLD Australia.; Conjoint Internal Medicine Laboratory, Chemical Pathology Pathology Queensland Herston QLD Australia.; Institute of Molecular Biosciences University of Queensland Saint Lucia QLD Australia., Smith C; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia., Khanna R; Faculty of Medicine University of Queensland Herston QLD Australia.; Tumour Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia.
Jazyk: angličtina
Zdroj: Clinical & translational immunology [Clin Transl Immunology] 2024 Nov 19; Vol. 13 (11), pp. e70015. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).
DOI: 10.1002/cti2.70015
Abstrakt: Objectives: Dysregulation of Epstein-Barr virus (EBV)-specific cellular immunity has been hypothesised as one of the contributing factors in the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis is a major risk factor for overall morbidity in SLE. Immune-based strategies directed to EBV have been proposed as potential therapeutic strategy for SLE and lupus nephritis.
Methods: Autologous EBV latent antigen-specific CD4 + and CD8 + T cells were expanded in vitro and adoptively transferred to a lupus nephritis patient.
Results: This adoptive immunotherapy had no immediate adverse effects, and the patient was subsequently treated with the anti-CD20 antibody, obinutuzumab. The patient showed a reduction in anti-dsDNA antibodies and improved glomerular filtration rate but remained nephrotic. These observations were coincident with a reduction in anti-viral and global T-cell activation.
Conclusion: To our knowledge, this is the first report of the use of EBV-specific adoptive immunotherapy to treat a patient with lupus nephritis.
Competing Interests: RK and CS are listed as inventors on patents for adoptive T‐cell therapy for autoimmune diseases.
(© 2024 The Author(s). Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.)
Databáze: MEDLINE
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