Prognostic Significance of the Controlling Nutritional Status (CONUT) Score in Patients with Muscle-Invasive Bladder Cancer after Radical Cystectomy.
| Autor: | Yücel C; Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. meclecuy@hotmail.com., Dumanli E; Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. enesdumanli35@gmail.com., Karabacak MC; Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. karabacak.mc@gmail.com., Akbay EK; Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. esatkaanakbay@yahoo.com., Yoldas M; Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. yoldas_2297@hotmail.com., Micoogullari U; Department of Urology, Can Hospital, Izmir Turkey. uygarmico@hotmail.com., Ilbey YO; Department of Urology, Bezmialem Vakıf University, Istanbul Turkey. ozlemyusufilbey@hotmail.com., Keskin MZ; Department of Urology, Health Sciences University Tepecik Training and Research Hospital, Izmir Turkey. zeynel_akd@hotmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Urology journal [Urol J] 2024 Nov 16. Date of Electronic Publication: 2024 Nov 16. |
| DOI: | 10.22037/uj.v21i.8266 |
| Abstrakt: | Purpose: To assess the impact of the The Controlling Nutritional Status (CONUT) score, an indicator of nutritional status, on the survival and prognosis after radical cystectomy. Materials and Methods: The medical records of patients who underwent consecutive radical cystectomy operations with the diagnosis of muscle-invasive bladder cancer at our clinic were retrospectively examined. The patients were separated into two groups based on the cut-off CONUT score which was derived using the receiver operating characteristic (ROC) curve. The group with a CONUT score ≥ 3 was categorized as high CONUT, whereas the group with a CONUT score < 3 was categorized as low CONUT. The groups were compaired according to oncological outcomes and survival risk factors. Results: Cancer-specific survival (CSS) and overall survival (OS) were statistically significantly lower in the High CONUT group compared to the Low CONUT group (p<0.001, p=0.024, respectively). Age (HR: 1.02, 95% CI: 1.006-1.04, p=0.011) and CONUT score (HR: 3.92, 95% CI: 2.66-5.77, p<0.001) were revealed to be independent prognostic variables in the multivariate analysis for OS. Conclusion: The CONUT score was found to be an independent predictor of survival in patients with muscle-invasive bladder cancer in this study. |
| Databáze: | MEDLINE |
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