Evaluating the Therapeutic Potential of Microneedle Patch Laser With Multiple Wavelengths in Allergic Rhinitis: Insights From an Allergic Rhinitis Mouse Model.

Autor: Ventura R; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Bae JS; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Kim EH; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Kim AY; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Oh MH; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Kim JH; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Yoo SH; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea., Ryu G; Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Mo JH; Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Korea.; Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Korea.
Jazyk: angličtina
Zdroj: Lasers in surgery and medicine [Lasers Surg Med] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1002/lsm.23862
Abstrakt: Objective: There is insufficient evidence to determine the effectiveness of treating allergic rhinitis with a patch laser affix to the skin as opposed to direct intranasal irradiation of the nasal mucosa. We aimed to evaluate the effect of the microneedle patch laser with multiple wavelengths in an allergic rhinitis (AR) mouse model and its underlying mechanism.
Methods: The microneedle patch laser was attached to the skin above the mouse's nasal cavity, transmitting light to the nasal mucosa. For 10 days, the microneedle patch laser administered simultaneous exposure to wavelengths of 670, 780, 850, and 910 nm at either 10 or 20 min each day. Multiple allergic parameters were evaluated following the microneedle patch laser treatment.
Results: Microneedle patch laser treatment decreased allergic symptoms and inhibited OVA-specific IgE levels. Additionally, it significantly reduced eosinophil infiltration, epithelial thickness of the nasal mucosa, and IL-4 cytokine levels.
Conclusion: The light emitted by the microneedle patch laser attached to the skin, penetrated effectively to the nasal mucosa within the nasal cavity, suggesting potential for treating allergic rhinitis in mice and could be extended in clinical applications.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: