A top-down slow breathing circuit that alleviates negative affect in mice.

Autor: Jhang J; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Park S; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Liu S; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.; Department of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA., O'Keefe DD; Research Development Department, The Salk Institute for Biological Studies, La Jolla, CA, USA., Han S; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. sunghan@salk.edu.; Department of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA. sunghan@salk.edu.; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea. sunghan@salk.edu.; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. sunghan@salk.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Dec; Vol. 27 (12), pp. 2455-2465. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1038/s41593-024-01799-w
Abstrakt: Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a top-down breathing pathway from dorsal anterior cingulate cortex (dACC) neurons to pontine reticular nucleus GABAergic inhibitory neurons (PnC GABA ), which then project to the ventrolateral medulla (VLM). dACC→PnC activity correlates with slow breathing cycles and volitional orofacial behaviors and is influenced by anxiogenic conditions. Optogenetic stimulation of the dACC→PnC GABA →VLM circuit simultaneously slows breathing and suppresses anxiety-like behaviors, whereas optogenetic inhibition increases both breathing rate and anxiety-like behaviors. These findings suggest that the dACC→PnC GABA →VLM circuit has a crucial role in coordinating slow breathing and reducing negative affect. Our study elucidates a circuit basis for top-down control of breathing, which can influence emotional states.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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