Fabrication and X-ray microtomography of sandwich-structured PEEK implants for skull defect repair.

Autor: Qi ML; School of Civil Engineering, Shandong Jiaotong University, Jinan, 250357, China.; National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 251100, China., Li M; School of Civil Engineering, Shandong Jiaotong University, Jinan, 250357, China., Yuan K; National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 251100, China., Song E; National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 251100, China., Zhang H; National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 251100, China. zhanghaijun@tongji.edu.cn.; Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. zhanghaijun@tongji.edu.cn., Yao S; Shandong Provincial Engineering and Technical Center of Light Manipulations & Shandong Provincial Key Laboratory of Optics and Photonic Device, School of Physics and Electronics, Shandong Normal University, Jinan, 250014, China. yaoshk@sdnu.edu.cn.; Collaborative Innovation Center of Light Manipulation and Applications, Shandong Normal University, Jinan, 250358, China. yaoshk@sdnu.edu.cn.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 19; Vol. 14 (1), pp. 28585. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1038/s41598-024-80103-z
Abstrakt: Bone defects pose a significant risk to human health. Medical polyetheretherketone (PEEK) is an excellent implant material for bone defect repair, but it faces the challenge of bone osteoconduction and osseointegration. Osteoconduction describes the process by which bone grows on the surface of the implant, while osseointegration is the stable anchoring of the implant achieved by direct contact between the bone and the implant. Bone defects repair depends on the implant's three-dimensional spatial structure, including pore size, porosity, and interconnections to a great extent. However, it is challenging to fabricate the porous structures to meet specific requirements and to characterize them without causing damage. In this study, we designed and fabricated sandwich-like PEEK implants mimicking the three-layer structures of the skull, whose defects imposes a significant burden on young adulthood and paediatric populations, and performed in-line phase-contrast synchrotron X-ray microtomography to non-destructively investigate the internal porous microstructures. The sandwich-like three-layer microstructure, comprising a dense layer, a loose layer and a dense layer in succession, exhibits structural similarity to that in a natural skull. This work demonstrated the fabrication of the sandwich-like PEEK implant that could potentially enhance osteoconduction and osseointegration. Furthermore, the interior structures and residual porogen sodium chloride particles were observed within the PEEK implant, which cannot be realized by other microscopic methods without destroying the sample. It highlights the advantages and potential of using synchrotron X-ray microtomography to analyze the structure of biomedical materials. This study provides theoretical guidance for the further design and fabrication of PEEK bone repair materials and will advance the clinical application of innovative bioactive bone repair materials.
Competing Interests: Declarations Competing interests The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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