Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.

Autor: Stedehouder J; Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK., Roberts BM; Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK., Raina S; Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Bossi S; Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Liu AKL; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Doig NM; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 3QT, UK., McGerty K; Mathematical Institute, University of Oxford, Oxford, OX2 6GG, UK., Magill PJ; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 3QT, UK., Parkkinen L; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK., Cragg SJ; Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK. stephanie.cragg@dpag.ox.ac.uk.; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK. stephanie.cragg@dpag.ox.ac.uk.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. stephanie.cragg@dpag.ox.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Nov 19; Vol. 15 (1), pp. 10017. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1038/s41467-024-54253-7
Abstrakt: Astrocytes are increasingly appreciated to possess underestimated and important roles in modulating neuronal circuits. Astrocytes in striatum can regulate dopamine transmission by governing the extracellular tone of axonal neuromodulators, including GABA and adenosine. However, here we reveal that striatal astrocytes occupy a cell type-specific anatomical and functional relationship with cholinergic interneurons (ChIs), through which they rapidly excite ChIs and govern dopamine release via nicotinic acetylcholine receptors on subsecond timescales. We identify that ChI somata are in unexpectedly close proximity to astrocyte somata, in mouse and human, forming a "soma-to-soma" satellite-like configuration not typically observed for other striatal neurons. We find that transient depolarization of astrocytes in mouse striatum reversibly regulates ChI excitability by decreasing extracellular calcium. These findings reveal a privileged satellite astrocyte-interneuron interaction for striatal ChIs operating on subsecond timescales via regulation of extracellular calcium dynamics to shape downstream striatal circuit activity and dopamine signaling.
Competing Interests: Competing interests The authors declare no competing interests. Inclusion and diversity We support inclusive, diverse, and equitable conduct of research.
(© 2024. The Author(s).)
Databáze: MEDLINE
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