Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats.

Autor: Tello-Palencia MA; Department of Statistics, Faculty of Science, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Yang T; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Sularz O; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.; Department of Human Nutrition and Dietetics, Faculty of Food Technology, University of Agriculture in Krakow, Krakow, 31-120, Poland., Demers LE; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.; Department of Parasitology, McGill University, Montreal, QC, H9X 3V9, Canada., Ma Y; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Boycott C; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Zhang HA; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Lubecka-Gajewska K; Department of Biomedical Chemistry, Medical University of Lodz, Lodz, 92-215, Poland., Kumar S; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Ramsey BS; Purdue University Institute for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA., Torregrosa-Allen S; Purdue University Institute for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA., Elzey BD; Purdue University Institute for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA., Lanman NA; Purdue University Institute for Cancer Research, Purdue University, West Lafayette, IN, 47906, USA.; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA., Korthauer K; Department of Statistics, Faculty of Science, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.; Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Vancouver, BC, V6H 0B3, Canada., Stefanska B; Food, Nutrition and Health Program, Faculty of Land and Food Systems, the University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2024 Dec; Vol. 68 (24), pp. e2400662. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1002/mnfr.202400662
Abstrakt: Scope: Polyphenols from the phytoestrogen group, including pterostilbene (PTS), are known for their antioxidant, anti-inflammatory, and anti-cancer effects. In recent reports, phytoestrogens attenuate age-related diseases; however, their pro-longevity effects in healthy models in mammals remain unknown. As longevity research demonstrates age-related transcriptomic signatures in human blood, the current study hypothesizes that phytoestrogen-supplemented diet may induce changes in gene expression that ultimately confer pro-longevity benefits.
Methods and Results: In the present study, RNA sequencing is conducted to determine transcriptome-wide changes in gene expression in whole blood of healthy rats consuming diets supplemented with phytoestrogens. Ortholog cell deconvolution is applied to analyze the omics data. The study discovered that PTS leads to changes in the gene expression landscape and PTS-target genes are associated with functions counteracting hallmarks of aging, including genomic instability, epigenetic alterations, compromised autophagy, mitochondrial dysfunction, deregulated nutrient sensing, altered intercellular interaction, and loss of proteostasis. These functions bridge together under anti-inflammatory effects through multiple pathways, including immunometabolism, where changes in cellular metabolism (e.g., ribosome biogenesis) impact the immune system.
Conclusion: The findings provide a rationale for pre-clinical and clinical longevity studies and encourage investigations on PTS in maintaining cellular homeostasis, decelerating the process of aging, and improving conditions with chronic inflammation.
(© 2024 The Author(s). Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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