Consumption of plant sterols-enriched soy milk with a healthy dietary pattern diet lowers blood pressure in adults with metabolic syndrome: A randomized controlled trial.
| Autor: | Xu Y; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore., Sutanto CN; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore., Xia X; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China., Toh DWK; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore., Gan AX; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore., Deng Q; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore., Ling LH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cardiology, National University Heart Centre, Singapore., Khoo CM; Division of Endocrinology, University Medicine Cluster, National University Hospital, Singapore., Foo RS; Department of Cardiology, National University Heart Centre, Singapore., Kim JE; Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore. Electronic address: fstkje@nus.edu.sg. |
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| Jazyk: | angličtina |
| Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2025 Jan; Vol. 35 (1), pp. 103773. Date of Electronic Publication: 2024 Oct 16. |
| DOI: | 10.1016/j.numecd.2024.10.011 |
| Abstrakt: | Background & Aims: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS. Methods and Results: This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 ± 3.7 mmHg; control group: 5.9 ± 2.5 mmHg (P Conclusions: Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS. Clinical Trial Registration: NCT03723330, https://clinicaltrials.gov/. Competing Interests: Declaration of competing interest The authors declare that they have no competing interests. (Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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