The biological effects of copper alloying in Zn-based biodegradable arterial implants.

Autor: Morath L; Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA. Electronic address: lmmorath@mtu.edu., Rahim SA; Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA., Baker C; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA., Anderson DEJ; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA., Hinds MT; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA., Sikora-Jasinska M; Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA., Oujiri L; Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA., Leyssens L; Biomechanics lab (MEED), Institute of Mechanics, Materials and Civil Engineering (iMMC), UCLouvain, Louvain-la-Neuve, Belgium; Pole of Morphology (MORF), Institute of Experimental and Clinical Research, UCLouvain, Brussels, Belgium; Department of Materials Engineering, KU Leuven, Heverlee, Belgium; Prometheus, Division for Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium., Kerckhofs G; Biomechanics lab (MEED), Institute of Mechanics, Materials and Civil Engineering (iMMC), UCLouvain, Louvain-la-Neuve, Belgium; Pole Materials and Processes Engineering (IMAP), iMMC, UCLouvain, Louvain-la-Neuve, Belgium., Pyka G; Department of Metallurgy and Materials Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenberg 44, B-3001 Leuven, Belgium., Oliver AA; Department of Biomedical Engineering and Physiology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA., Drelich JW; Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI 49931, USA., Goldman J; Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Jazyk: angličtina
Zdroj: Biomaterials advances [Biomater Adv] 2025 Feb; Vol. 167, pp. 214112. Date of Electronic Publication: 2024 Nov 08.
DOI: 10.1016/j.bioadv.2024.214112
Abstrakt: Biodegradable metals based on zinc are being developed to serve as temporary arterial scaffolding. Although the inclusion of copper is becoming more prevalent for grain refinement in zinc alloys, the biological activity of the copper component has not been well investigated. Here, two ZnCu alloys (0.8 and 1.5 wt% Cu) with and without thermal treatment were investigated for their hemocompatibility and biocompatibility. The microstructure was examined using scanning electron microscopy and X-ray diffraction. Zn-1.5Cu was found to contain nearly double the amount of second phase (CuZn 5 ) precipitates as compared to Zn-0.8Cu. Thermal treatment dissolved a portion of the precipitates into the matrix. Since copper is a well-known catalyst for NO generation, the metals were tested both for their ability to generate NO release and for their thrombogenicity. Cellular responses and in vivo corrosion were characterized by a 6 months in vivo implantation of metal wires into rat arteries. The as-received Zn-1.5Cu displayed the least neointimal growth and smooth muscle cell presence, although inflammation was slightly increased. Thermal treatment was found to worsen the biological response, as determined by an increased neointimal size, increased smooth muscle cell presence and small regions of necrotic tissue. There were no trends in NO release between the alloys and thermal treatments. Corrosion progressed predominately through a pitting mechanism in vivo, which was more pronounced for the thermally treated alloys, with a more uniform corrosion seen for as-received Zn-1.5Cu. Differences in biological response are speculated to be due to changes in microstructure and pitting corrosion behavior.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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