Inflammatory signalling during the perinatal period: Implications for short- and long-term disease risk.

Autor: Garcia de Leon R; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada., Hodges TE; Mount Holyoke College, South Hadley, MA, USA., Brown HK; University of Toronto, Toronto, ON, Canada., Bodnar TS; University of Calgary, Calgary, AB, Canada., Galea LAM; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. Electronic address: liisa.galea@camh.ca.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2024 Nov 15; Vol. 172, pp. 107245. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1016/j.psyneuen.2024.107245
Abstrakt: During pregnancy and the postpartum, there are dynamic fluctuations in steroid and peptide hormone levels as well as inflammatory signalling. These changes are required for a healthy pregnancy and can persist well beyond the postpartum. Many of the same hormone and inflammatory signalling changes observed during the perinatal period also play a role in symptoms related to autoimmune disorders, psychiatric disorders, and perhaps neurodegenerative disease later in life. In this review, we outline hormonal and immunological shifts linked to pregnancy and the postpartum and discuss the possible role of these shifts in increasing psychiatric, neurodegenerative disease risk and autoimmune symptoms during and following pregnancy. Furthermore, we discuss how key variables such as the number of births (parity) and sex of the fetus can influence inflammatory signalling, and possibly future disease risk, but are not often studied. We conclude by discussing the importance of studying female experiences such as pregnancy and parenting on physiology and disease.
Competing Interests: Declaration of Competing Interest None of the authors declare any conflicts of interest
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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