Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.

Autor: Dickey CW; Neurosciences Graduate Program, University of California San Diego, La Jolla, California, United States of America.; Medical Scientist Training Program, University of California San Diego, La Jolla, California, United States of America.; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, United States of America., Verzhbinsky IA; Neurosciences Graduate Program, University of California San Diego, La Jolla, California, United States of America.; Medical Scientist Training Program, University of California San Diego, La Jolla, California, United States of America., Kajfez S; Department of Radiology, University of California San Diego, La Jolla, California, United States of America., Rosen BQ; Neurosciences Graduate Program, University of California San Diego, La Jolla, California, United States of America.; Department of Neuroscience, Washington University in St. Louis, St. Louis, Missouri, United States of America., Gonzalez CE; Neurosciences Graduate Program, University of California San Diego, La Jolla, California, United States of America., Chauvel PY; Aix-Marseille Université, Marseille, France.; INSERM, Institut de Neurosciences des Systèmes UMR 1106, Marseille, France.; APHM (Assistance Publique-Hôpitaux de Marseille), Timone Hospital, Marseille, France., Cash SS; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Pati S; Department of Neurology, University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Halgren E; Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, United States of America.; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Jazyk: angličtina
Zdroj: PLoS biology [PLoS Biol] 2024 Nov 19; Vol. 22 (11), pp. e3002855. Date of Electronic Publication: 2024 Nov 19 (Print Publication: 2024).
DOI: 10.1371/journal.pbio.3002855
Abstrakt: In the neocortex, ~90 Hz ripples couple to ~12 Hz sleep spindles on the ~1 Hz Down-to-Up state transition during non-rapid eye movement sleep. This conjunction of sleep waves is critical for the consolidation of memories into long-term storage. The widespread co-occurrences of ripples ("co-ripples") may integrate information across the neocortex and hippocampus to facilitate consolidation. While the thalamus synchronizes spindles and Up states in the cortex for memory, it is not known whether it may also organize co-ripples. Using human intracranial recordings during NREM sleep, we investigated whether cortico-cortical co-ripples and hippocampo-cortical co-ripples are either: (1) driven by directly projected thalamic ripples; or (2) coordinated by propagating thalamic spindles or Up states. We found ripples in the anterior and posterior thalamus, with similar characteristics as hippocampal and cortical ripples, including having a center frequency of ~90 Hz and coupling to local spindles on the Down-to-Up state transition. However, thalamic ripples rarely co-occur or phase-lock with cortical or hippocampal ripples. By contrast, spindles and Up states that propagate from the thalamus strongly coordinate co-ripples in the cortex and hippocampus. Thus, thalamo-cortical spindles and Up states, rather than thalamic ripples, may provide input facilitating spatially distributed co-rippling that integrates information for memory consolidation during sleep in humans.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Dickey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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