Association of IL1RN VNTR and NKG2A polymorphisms with hepatitis E infection, a case study from western India.

Autor: Tripathy AS; ICMR-National Institute of Virology, Pune, Maharashtra, India. anuradhastripathy@hotmail.com., Wagh P; ICMR-National Institute of Virology, Pune, Maharashtra, India., Shahapure G; ICMR-National Institute of Virology, Pune, Maharashtra, India., Walimbe AM; ICMR-National Institute of Virology, Pune, Maharashtra, India., Kadgi N; BJMC and Sassoon General Hospital, Pune, Maharashtra, India., Nakate L; BJMC and Sassoon General Hospital, Pune, Maharashtra, India.
Jazyk: angličtina
Zdroj: Archives of virology [Arch Virol] 2024 Nov 19; Vol. 169 (12), pp. 250. Date of Electronic Publication: 2024 Nov 19.
DOI: 10.1007/s00705-024-06179-0
Abstrakt: Interleukin 1 receptor antagonist (IL1RN) is a competitive inhibitor of interleukin 1 (IL-1). Natural killer cells (NK cells) contribute to the elimination of viruses by their antiviral effector function, which depends on a balance between inhibitory and activating receptor genes such as NKG2D and NKG2A. Using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assays, the association of intronic single-nucleotide polymorphisms (SNPs) in these genes with viral infection were assessed in 111 patients with hepatitis E virus (HEV) infection and 222 HEV-naive healthy controls. An SNP in the IL1RN (VNTR) gene revealed allele 2 to be associated with protection against HEV infection (IL1RN *1/*1 vs. IL1RN *2/*2, OR = 0.26, 95% CI = 0.14-0.47, p < 0.001). Similarly, a polymorphism in the intronic region of NKG2A revealed an association with protection in a co-dominant model (A/A vs. A/G: OR = 0.40; 95% CI = 0.24-0.67; A/A vs. G/G: OR = 0.25; 95% CI = 0.10-0.57; p < 0.05) and an association with susceptibility in a dominant model (A/A + A/G vs. G/G: OR = 2.28; 95% CI = 1.06-4.93; p < 0.05) and a recessive model (AA vs. AG + GG: OR = 2.71; 95% CI = 1.66-4.48; p < 0.001). Our data suggest that genetic polymorphisms in host NKG2A and IL1RN have both protective and detrimental roles in HEV infection, although their impact on disease outcome remains unknown.
Competing Interests: Declarations Ethics statement This study was approved by the Institutional Ethical Committee for Research on Humans, based on the guidelines set by the Indian Council of Medical Research, New Delhi. Informed written consent was obtained from all study participants. Conflict of interest The authors do not have any conflict of interest.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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