| Autor: |
Peras M; 1Department of Microbiology, Institute of Public Health Zagreb County, 10 290 Zaprešić, Croatia., Kuliš T; 2Department of Urology, University Hospital Centre Zagreb, 10 000 Zagreb, Croatia., Mareković I; 3Department of Clinical Microbiology, Infection Prevention and Control, University Hospital Centre Zagreb, 10 000 Zagreb, Croatia.; 4School of Medicine, University of Zagreb, 10 000 Zagreb, Croatia. |
| Jazyk: |
angličtina |
| Zdroj: |
Acta microbiologica et immunologica Hungarica [Acta Microbiol Immunol Hung] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19. |
| DOI: |
10.1556/030.2024.02417 |
| Abstrakt: |
Bloodstream infections (BSI) result in significant morbidity and mortality rates, and delayed administration of appropriate antimicrobial treatment is a major predictor of poor outcomes. T2 magnetic resonance (T2MR®) (T2 Biosystems®, Lexington, MA, USA) is an innovative technology that can rapidly identify pathogens from a sample of whole blood in a remarkably short time frame of 3-5 h. We are evaluating if the T2Bacteria Panel (T2BP) contributes to the etiological diagnosis of bloodstream infections when combined with standard blood cultures (BC). The study was performed between December 2018 and March 2019, and a total of 28 patients with suspected BSI were included. The most notable finding of our study was that the addition of T2BP to BC in a diagnostic workflow led to a statistically significant higher rate of T2BP-targeted bacteria identification in patients with suspected BSI (46.4% versus 7.1%, P = 0.001) when compared to BC alone. Considering the measures of diagnostic accuracy, T2BP showed 100.00% sensitivity, 88.24% specificity, 100% negative predictive value (NPV), and 84.62% positive predictive value (PPV). Our findings give valuable insights for microbiologists and clinicians into this molecular method and its advantages in routine diagnostics of BSI. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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