A retrospective study of recombinant human growth hormone in the treatment of school-aged pediatric patients with idiopathic short stature.

Autor:	Chen Y; Department of Pediatrics, Hubei Traditional Chinese Medicine Hospital (Hubei Institute of Traditional Chinese Medicine, Hubei University of Chinese Medicine Hospital), Hubei, Wuhan, China., Li YH; Clinical College of Chinese Medicine, Hubei Sizhen Laboratory, Hubei University of Traditional Chinese Medicine, Hubei, Wuhan, China., Zhang XR; Department of First Clinical College, Hubei Sizhen Laboratory, Hubei University of Traditional Chinese Medicine, Hubei, Wuhan, China.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Nov 15; Vol. 103 (46), pp. e40545.
DOI:	10.1097/MD.0000000000040545
Abstrakt:	The present study aims to investigate the clinical efficacy of recombinant human growth hormone (r-hGH) in the treatment of school-age pediatric patients with idiopathic short stature (ISS). Pediatric patients who were diagnosed with ISS and treated with r-hGH at our hospital were enrolled as research subjects. The main outcome indicators included the serum level of insulin-like growth factor-1, insulin-like growth factor binding protein-3, baseline height standard deviation scores, and posttreatment height standard deviation scores and retrospective analysis was performed. This study complies with the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. A total of 42 pediatric patients with a diagnosis of ISS were enrolled in the present study (24 males and 18 females). Following treatment, the levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 were significantly higher than the baseline level and the difference was statistically significant. The posttreatment height standard deviation scores was significantly higher than the baseline height standard deviation scores and the difference was statistically significant. There were no significant differences between male and female participants in height standard deviation scores, either before or following treatment. This study found that r-hGH therapy may increase height in school-age pediatric patients with ISS and is therefore worthy of clinical application. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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