Weight maintenance on cost-effective antiobesity medications after 1 year of GLP-1 receptor agonist therapy: a real-world study.

Autor: Paddu NU; Department of Medicine, Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Vanderbilt Weight Loss Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Lawrence B; Vanderbilt Weight Loss Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wong S; Department of Medicine, Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Poon SJ; Department of Population Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Srivastava G; Department of Medicine, Division of Diabetes, Endocrinology & Metabolism, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Vanderbilt Weight Loss Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Dec; Vol. 32 (12), pp. 2255-2263. Date of Electronic Publication: 2024 Nov 18.
DOI: 10.1002/oby.24177
Abstrakt: Objective: The high cost of novel glucagon-like peptide-1 receptor agonist (GLP-1 RA) class agents often limits access and creates barriers to care. This real-world study evaluated the efficacy of older-generation generic antiobesity medications (AOMs) for weight maintenance after 1 year of GLP-1 RA therapy in patients who had achieved successful weight loss.
Methods: We prospectively followed patients (N = 105) who had completed 12 months of therapy and were part of a "medical weight loss bundle," which included 12 months of GLP-1 RA therapy followed by 6 months of transition care. The baseline mean BMI was 36.4 kg/m 2 . Body weight outcomes were measured at 6, 12, 18, and 24 months.
Results: After the medical weight loss bundle, 40 patients transitioned to generic AOMs. At 12 months, this cohort lost an average of 18.3%, 95% CI [13.0%, 23.6%] body weight from baseline, with a mean BMI of 27.9 kg/m 2 . At 18 months, they maintained the weight loss, with a mean BMI of 27.9 kg/m 2 . Subsequent follow-up visits (average 1.5 months later) without GLP-1 RAs showed further reduction, resulting in a total average weight loss of 25.5%, 95% CI [23.1%, 27.9%] compared to the initial visit.
Conclusions: Patients successfully treated with GLP-1 RAs can maintain their weight loss using generic older-generation AOMs, suggesting potential cost savings for insurers and implications for policy regarding AOM coverage.
(© 2024 The Author(s). Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.)
Databáze: MEDLINE
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