A review on the potential use of bismuth nanoparticles in oral health.

Autor: Albadr RJ; Ahl al Bayt University, Kerbala, Iraq., Taher WM; College of Nursing, National University of Science and Technology, Dhi Qar, Iraq., Alwan M; Pharmacy College, Al-Farahidi University, Iraq., Jawad MJ; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq., Mushtaq H; Gilgamesh Ahliya University, Baghdad, Iraq., Yaseen BM; Department of Medical Laboratory Technics, College of Health and Medical Technology, Alnoor University, Mosul, Iraq. Electronic address: baraamohammadyaseen@gmail.com.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2024 Nov 16; Vol. 198, pp. 107131. Date of Electronic Publication: 2024 Nov 16.
DOI: 10.1016/j.micpath.2024.107131
Abstrakt: According to many investigations, persistent oral infections may be caused by oral pathogenic biofilms. Irritation of soft tissues and subsequent bone resorption due to bacterial biofilm contamination of the implant further worsen oral health. Dental problems may be effectively treated using metal nanoparticles (NPs) because they limit the development of many different types of bacteria. With their low toxicity, X-ray sensitivity, high atomic number, near-infrared driven semiconductor qualities, and cheap cost, multifunctional bismuth (Bi) NPs with therapeutic activities show significant potential for the domains of bacterial infection diagnostics and treatment. Also, by directly communicating with the bacterial cell wall, stimulating intracellular effects, inhibiting biofilm formation, producing reactive oxygen species, and inducing adaptive and innate immune responses, BiNPs offer an alternative to conventional antibiotics for treating bacteria with multiple drug resistance (MDR). Hence, BiNPs, which have more antibacterial activity and fewer side effects than chlorhexidine, might be a promising option to fight biofilm-forming bacteria in the mouth. This could lead to their usage in several areas of dentistry. The research delves into the many synthesis techniques of BiNPs and their antibacterial and anticancer capabilities. Next, we'll review how this nanoparticle has helped with dental infections, periodontitis, and dental implant problems. The anticancer effects of BiNPs on oral cancer were also studied. Thus, after this paper, we have highlighted the therapeutic limits and ways to address this issue for the clinical success of BiNPs in promoting oral and dental health.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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