Influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism: a cohort study.

Autor:	Araujo-Castro M; Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid 28034, Spain.; Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid 28034, Spain., Paja Fano M; Endocrinology & Nutrition Department, OSI Bilbao-Basurto, Hospital Universitario de Basurto, Bilbao 48013, Spain.; University of the Basque Country UPV/EHU, Bilbao 48013, Spain., González-Boillos M; Endocrinology & Nutrition Department, Hospital Universitario de Castellón, Castellón 12004, Spain., Pascual-Corrales E; Endocrinology & Nutrition Department, Hospital Universitario Ramón y Cajal, Madrid 28034, Spain.; Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Madrid 28034, Spain., Parra Ramírez P; Endocrinology & Nutrition Department, Hospital Universitario La Paz, Madrid 28046, Spain., Martín Rojas-Marcos P; Endocrinology & Nutrition Department, Hospital Universitario La Paz, Madrid 28046, Spain., García-Cano A; Biochemistry Department, Hospital Universitario Ramón y Cajal, Madrid 28034, Spain., Ruiz-Sanchez JG; Endocrinology & Nutrition Department, Hospital Universitario Fundación Jiménez Díaz, Madrid 28040, Spain., Vicente A; Endocrinology & Nutrition Department, Hospital Universitario de Toledo, Toledo 45007, Spain., Gómez-Hoyos E; Endocrinology & Nutrition Department, Hospital Universitario de Valladolid, Valladolid 47003, Spain., Casterás A; Endocrinology & Nutrition Department, Hospital Val de Hebrón, Barcelona 08035, Spain., Puig-Perez A; Endocrinology & Nutrition Department, Hospital Val de Hebrón, Barcelona 08035, Spain., García Sanz I; General & Digestive Surgery Department, Hospital Universitario de La Princesa, Madrid 28006, Spain., Recasens M; Endocrinology & Nutrition Department, Hospital De Girona Doctor Josep Trueta, Girona 17007, Spain., Barahona San Millan R; Endocrinology & Nutrition Department, Hospital De Girona Doctor Josep Trueta, Girona 17007, Spain., Picón César MJ; Endocrinology & Nutrition Department, Hospital Universitario Virgen de la Victoria de Málaga, IBIMA, Malaga 29010, Spain.; CIBEROBN, Madrid 29010, Spain., Díaz Guardiola P; Endocrinology & Nutrition Department, Hospital Universitario Infanta Sofía, Madrid 28702, Spain., Perdomo C; Endocrinology & Nutrition Department, Clínica Universidad de Navarra, Pamplona 28027, Spain., Manjón-Miguélez L; Endocrinology & Nutrition Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias 33011, Spain., Rebollo Román Á; Endocrinology & Nutrition Department, Hospital Reina Sofía, Córdoba 14004, Spain., Robles Lázaro C; Endocrinology & Nutrition Department, Hospital Clínico Universitario de Salamanca, Salamanca 37007, Spain., María Recio J; Endocrinology & Nutrition Department, Hospital Clínico Universitario de Salamanca, Salamanca 37007, Spain., Morales-Ruiz M; Biochemistry and Molecular Genetics Department-CDB, Hospital Clinic, IDIBAPS, CIBERehd, Barcelona 08036, Spain., Calatayud M; Endocrinology & Nutrition Department, Hospital Doce de Octubre, Madrid 28041, Spain., Jiménez López N; Endocrinology & Nutrition Department, Hospital Doce de Octubre, Madrid 28041, Spain., Meneses D; Endocrinology & Nutrition Department, Hospital Universitario Fundación Jiménez Díaz, Madrid 28040, Spain., Sampedro Nuñez M; Endocrinology & Nutrition Department, Hospital Universitario La Princesa, Madrid 28006, Spain., Ribas EM; Endocrinology & Nutrition Department, Hospital Universitario Son Espases, Islas Baleares 07120, Spain., Sanmartín Sánchez A; Endocrinology & Nutrition Department, Hospital Universitario Son Espases, Islas Baleares 07120, Spain., Gonzalvo Diaz C; Endocrinology & Nutrition Department, Complejo Hospitalario Universitario de Albacete, Albacete 02008, Spain., Lamas C; Endocrinology & Nutrition Department, Complejo Hospitalario Universitario de Albacete, Albacete 02008, Spain., Del Castillo Tous M; Endocrinology & Nutrition Department, Hospital Universitario Virgen Macarena, Seville 41009, Spain., Serrano J; Endocrinology & Nutrition Department, Hospital General Universitario de Alicante, Alicante 03010, Spain., Michalopoulou T; Endocrinology & Nutrition Department, Hospital Joan XXIII, Tarragona 03550, Spain., Tenes Rodrigo S; Endocrinology & Nutrition Department, Hospital La Fé, Valencia 46026, Spain., Roa Chamorro R; Internal Medicine Department, Hospital Universitario Virgen de las Nieves, Granada 18014, Spain., Jaén Aguila F; Internal Medicine Department, Hospital Universitario Virgen de las Nieves, Granada 18014, Spain., Moya Mateo EM; Internal Medicine, Hospital Universitario Infanta Leonor, Madrid 28031, Spain., Gutiérrez-Medina S; Endocrinology & Nutrition Department, Clínica Universidad de Navarra, Madrid 28027, Spain., Hanzu FA; Endocrinology & Nutrition Department, Hospital Clinic, University of Barcelona, IDIPAS, Barcelona 08036, Spain.
Jazyk:	angličtina
Zdroj:	European journal of endocrinology [Eur J Endocrinol] 2024 Nov 27; Vol. 191 (6), pp. 579-587.
DOI:	10.1093/ejendo/lvae143
Abstrakt:	Aim: To evaluate the influence of smoking on cardiometabolic profile and surgical outcomes in patients with primary aldosteronism (PA). Methods: Multicentre retrospective study of patients with PA evaluated in 36 Spanish tertiary hospitals with available information on smoking habits [smokers and non-smokers (never smokers and ex-smokers)]. Results: A total of 881 patients were included, of whom 180 (20.4%) were classified as smokers and 701 as non-smokers. At diagnosis, smokers and non-smokers did not differ in blood pressure or serum potassium levels between. However, smokers had a higher prevalence of left ventricular hypertrophy (LVH) than non-smokers [odds ratio (OR) 2.0, 95% confidence interval (CI) 1.23-3.25], and smokers were more likely to have severe LVH than non-smokers (12.5% vs 6.6%, P = .164). A larger mean tumour size of the adrenal nodule/s was observed in the smoking group (18.6 ± 9.66 vs 15.8 ± 8.66 mm, P = .002). In addition, the odds of mild autonomous cortisol secretion (MACS) was greater in smokers than in non-smokers (OR 2.1, 95% CI 1.14-4.06), but these differences disappeared when adjusted for the size of the adrenal nodule/s (adjusted OR 1.6, 95% CI 0.76-3.37). The rate of biochemical and hypertension cure was similar in both groups; however, hypertension cure tended to be more frequent in the non-smoker group (41.2% vs 29.9%, P = .076). Conclusions: Patients with PA who smoke have a higher prevalence of LVH and MACS and larger adrenal nodule/s than non-smokers. Smoking has no significant effect on the probability of hypertension response after adrenalectomy in patients with PA; however, a tendency to a lower probability of hypertension cure is observed in smokers compared to non-smokers. Competing Interests: Conflict of interest: None declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology.)
Databáze:	MEDLINE
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