Is glucose-induced hypersecretion of glicentin after the revision surgery using Roux-en-Y gastric bypass related to improved glycemic control due to insulin hypersecretion in a type 2 diabetes patient without diabetes remission after laparoscopic sleeve gastrectomy?

Autor: Yamamoto Y; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan., Sekine O; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan., Ito-Kobayashi J; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan., Nishida A; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan., Togawa T; Department of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan., Ozamoto Y; Department of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan., Oe Y; Department of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan., Hagiwara A; Department of Bariatric and Metabolic Surgery, Omi Medical Center, Kusatsu, Shiga, Japan., Kobayashi M; Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan., Kitamura T; Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan., Iwanishi M; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan., Shimatsu A; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan., Kashiwagi A; Department of Diabetes and Endocrinology, Omi Medical Center, Kusatsu, Shiga, Japan.
Jazyk: angličtina
Zdroj: Journal of diabetes investigation [J Diabetes Investig] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.
DOI: 10.1111/jdi.14325
Abstrakt: We report case details of a morbidly obese patient with type 2 diabetes mellitus (T2DM) who became a failure of diabetes remission after laparoscopic sleeve gastrectomy (LSG). He had a marked improvement of hyperglycemia after the revision surgery using Roux-en-Y gastric bypass (RYGB), where passage failure of a solid food intake at the gastric angle portion disappeared after the revision surgery. Interestingly, he showed improvements of insulin and a marked glicentin secretions with minor changes in glucagon related peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) secretions in the oral glucose tolerance test OGTT after the RYGB surgery compared with post-LSG. Although a marked increase in glucose-induced glicentin secretion after RYGB surgery with increased insulin secretion, further studies are needed to confirm if the increased glicentin secretion after RYGB surgery is linked to stimulation of insulin secretion.
(© 2024 The Author(s). Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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